Sonata and Hydroxyzine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Sonata (zaleplon) and Hydroxyzine (hydroxyzine hydrochloride). Common drug interactions include dyspnoea among females and diabetes mellitus among males.

The phase IV clinical study analyzes what interactions people have when they take Sonata and Hydroxyzine. It is created by eHealthMe based on reports of 69 people who take the same drugs from the FDA, and is updated regularly.

What is Sonata?

Sonata has active ingredients of zaleplon. It is often used in insomnia. eHealthMe is studying from 3,330 Sonata users. Check the latest studies of Sonata.

What is Hydroxyzine?

Hydroxyzine has active ingredients of hydroxyzine hydrochloride. It is often used in stress and anxiety. eHealthMe is studying from 54,070 Hydroxyzine users. Check the latest studies of Hydroxyzine.

On Aug, 11, 2026

69 people who take Sonata and Hydroxyzine together, and have interactions are studied.

Sonata and Hydroxyzine drug interactions.

What are the common drug interactions of Sonata and Hydroxyzine, by gender? *:

female:

Dyspnoea (difficult or laboured respiration)
Abdominal pain
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cystitis interstitial (unknown cause characterized by bladder pain)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Dysuria (painful or difficult urination)
Fibromyalgia (a long-term condition which causes pain all over the body)
Gait disturbance
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Head injury

male:

Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diabetes mellitus inadequate control
Decreased appetite
Depression
Fall
Headache (pain in head)
Hypoaesthesia (reduced sense of touch or sensation)
Joint dislocation (a joint position is changed from normal position)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Quality of life decreased

What are the common drug interactions of Sonata and Hydroxyzine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Amenorrhoea (absence of a menstrual period in a woman of reproductive age)
Menstruation irregular

20-29:

Psychotic disorder
Aggression
Anaemia (lack of blood)
Anger
Arrhythmia (irregular heartbeat)
Asthma
Bipolar disorder (mood disorder)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cholecystitis chronic (long lasting infection of gallbladder)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)

30-39:

Decreased appetite
Hypoaesthesia (reduced sense of touch or sensation)
Pain in extremity
Weight decreased
Arthralgia (joint pain)
Depression
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diabetes mellitus inadequate control
Fall
Headache (pain in head)

40-49:

Type 2 diabetes mellitus
Abdominal pain upper
Cough
Decreased appetite
Depression
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Head injury
Hypertension (high blood pressure)
Increased appetite
Memory impairment

50-59:

Chronic kidney disease
Renal failure (kidney dysfunction)
Bile duct stenosis (abnormal narrowing of the common bile duct)
Chronic hepatitis (long lasting inflammation of liver)
Hepatic cirrhosis (chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue)
Pancreatic duct stenosis (abnormal narrowing of a passage in the pancreatic duct)
Sphincter of oddi dysfunction (dysfunction of a muscular valve that controls the flow of digestive juices)
Nephrogenic anaemia (anaemia due to kidney disease)
Biliary fibrosis
Drug hypersensitivity

60+:

Metastases to liver (cancer spreads to liver)
Pancreatic carcinoma metastatic (pancreatic cancer- metastatic)
Drug ineffective
Dyspepsia (indigestion)
Enuresis (repeated inability to control urination)
Fall
Gastric ulcer (stomach ulcer)
Gastritis (inflammation of stomach)
Hangover
Hospitalisation

What are the existing conditions these people have? *

Depression: 18 people, 26.09%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 13 people, 18.84%
Pain: 12 people, 17.39%
Nausea (feeling of having an urge to vomit): 12 people, 17.39%
High Blood Pressure: 10 people, 14.49%
Chronic Fatigue Syndrome (disorder that causes extreme fatigue): 9 people, 13.04%
Muscle Spasms (muscle contraction): 9 people, 13.04%
Type 2 Diabetes: 7 people, 10.14%
Irritable Bowel Syndrome: 7 people, 10.14%
Asthma: 7 people, 10.14%

* Approximation only. Some reports may have incomplete information.

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