Sonata and Hyzaar drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Sonata (zaleplon) and Hyzaar (hydrochlorothiazide; losartan potassium). Common drug interactions include oropharyngeal pain among females and candidiasis among males.

The phase IV clinical study analyzes what interactions people have when they take Sonata and Hyzaar. It is created by eHealthMe based on reports of 21 people who take the same drugs from the FDA, and is updated regularly.

What is Sonata?

Sonata has active ingredients of zaleplon. It is often used in insomnia. eHealthMe is studying from 3,330 Sonata users. Check the latest studies of Sonata.

What is Hyzaar?

Hyzaar has active ingredients of hydrochlorothiazide; losartan potassium. It is often used in high blood pressure. eHealthMe is studying from 16,614 Hyzaar users. Check the latest studies of Hyzaar.

On Jul, 13, 2026

21 people who take Sonata and Hyzaar together, and have interactions are studied.

What are the common drug interactions of Sonata and Hyzaar, by gender? *:

female:

Oropharyngeal pain
Pancreatitis (inflammation of pancreas)
Panic attack
Personality disorder
Plantar fasciitis (painful inflammatory process of the plantar fascia)
Polyp
Radiculitis cervical (inflammation of nerve root at cervical)
Radiculitis lumbosacral (inflammation of nerve root at labosacral vertebrea)
Rectal haemorrhage (bleeding from anus)
Depression

male:

Candidiasis (candidiasis or thrush is a fungal infection)
Cough
Weight decreased
Weight increased
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Drug ineffective
Dysgeusia (disorder of the sense of taste)
Hypersensitivity
Oral candidiasis (fungal infection of mouth)
Restless legs syndrome (a powerful urge to move your legs)

What are the common drug interactions of Sonata and Hyzaar, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Weight increased
Allergy to animal
Cough
Diabetic ulcer
Enuresis (repeated inability to control urination)
Faecal incontinence (a lack of control over passing stool)
House dust allergy
Inflammation
Lacrimation increased
Mood swings (an extreme or rapid change in mood)

50-59:

Hypersensitivity
Weight increased
Abdominal distension
Blood glucose increased
Burning sensation
Cardiomyopathy (weakening of the heart muscle)
Colitis ischaemic (due to infection of intestine impaired blood supply to colon)
Constipation
Depression
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)

60+:

Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Dizziness
Intervertebral disc disorder (spinal disc disorder)
Pneumonia
Spinal disorder (disease of spine a back bone)
Anaemia (lack of blood)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Blood cholesterol increased
Candidiasis (candidiasis or thrush is a fungal infection)
Chest pain

What are the existing conditions these people have? *

Pain: 5 people, 23.81%
Pain In Extremity: 4 people, 19.05%
Depression: 3 people, 14.29%
Stress And Anxiety: 2 people, 9.52%
Sleep Disorder: 2 people, 9.52%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 9.52%
Joint Pain: 2 people, 9.52%
Diabetes: 2 people, 9.52%

* Approximation only. Some reports may have incomplete information.

Do you take Sonata and Hyzaar?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously