Sonata and Morphine sulfate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Sonata (zaleplon) and Morphine sulfate (morphine sulfate). Common drug interactions include hypotension among females and anxiety among males.

The phase IV clinical study analyzes what interactions people have when they take Sonata and Morphine sulfate. It is created by eHealthMe based on reports of 55 people who take the same drugs from the FDA, and is updated regularly.

What is Sonata?

Sonata has active ingredients of zaleplon. It is often used in insomnia. eHealthMe is studying from 3,330 Sonata users. Check the latest studies of Sonata.

What is Morphine sulfate?

Morphine sulfate has active ingredients of morphine sulfate. It is often used in pain. eHealthMe is studying from 87,262 Morphine sulfate users. Check the latest studies of Morphine sulfate.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Jul, 02, 2026

55 people who take Sonata and Morphine sulfate together, and have interactions are studied.

Sonata and Morphine sulfate drug interactions.

What are the common drug interactions of Sonata and Morphine Sulfate, by gender? *:

female:

Hypotension (abnormally low blood pressure)
Sepsis (a severe blood infection that can lead to organ failure and death)
Anxiety
Aortic disorder
Bile duct stenosis (abnormal narrowing of the common bile duct)
Bradycardia (abnormally slow heart action)
Cardiac failure
Cardiac murmur (an heart sound in valve abnormality)
Cataplexy (loss of muscle tone accompanied by full conscious awareness)
Cerebral ventricle dilatation (enlargement of ventricle of brain)

male:

Anxiety
Dyspnoea (difficult or laboured respiration)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hypotension (abnormally low blood pressure)
Intervertebral disc degeneration (spinal disc degeneration)
Onychomycosis (fungal infection of the nail)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Pleural effusion (water on the lungs)
Sinusitis (inflammation of sinus)

What are the common drug interactions of Sonata and Morphine Sulfate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Anxiety
Constipation
Depression
Drug abuser
Drug dependence
Drug ineffective
Emotional distress
Fall
Hypoaesthesia (reduced sense of touch or sensation)
Muscle spasms (muscle contraction)

30-39:

Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diabetes mellitus inadequate control

40-49:

Anxiety
Depression
Chest pain
Dyspnoea (difficult or laboured respiration)
General physical health deterioration (weak health status)
Intervertebral disc degeneration (spinal disc degeneration)
Intervertebral disc protrusion (spinal disc protrusion)
Osteonecrosis of jaw (death of bone of jaw)
Rib fracture
Bone lesion (bone with abnormalities. bone lesions can result from growth formations, infections, or injuries)

50-59:

Blood cholesterol increased
Bone disorder
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cardiac failure congestive
Cardiac valve abscess (pus containing infection of heart valve)
Cataract (clouding of the lens inside the eye)
Chronic hepatitis (long lasting inflammation of liver)
Colitis ischaemic (due to infection of intestine impaired blood supply to colon)
Conjunctivitis (pink eye)
Constipation

60+:

Fall
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Loss of consciousness
Central nervous system lesion (an abnormality in tissue of brain or spinal cord)
Gastrointestinal infection (infection of stomach and intestine)
Hypersensitivity
Muscle fatigue (a condition in which muscles cannot exert their normal force)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Dizziness
Tooth fracture

What are the existing conditions these people have? *

Depression: 20 people, 36.36%
Nausea (feeling of having an urge to vomit): 17 people, 30.91%
Asthma: 16 people, 29.09%
Sleep Disorder: 15 people, 27.27%
Migraine (headache): 12 people, 21.82%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 11 people, 20.00%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 11 people, 20.00%
Stress And Anxiety: 10 people, 18.18%
High Blood Pressure: 8 people, 14.55%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 7 people, 12.73%

* Approximation only. Some reports may have incomplete information.

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