Sotalol hydrochloride and Toprol-xl drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Sotalol hydrochloride (sotalol hydrochloride) and Toprol-xl (metoprolol succinate). Common drug interactions include asthenia among females and blood lactate dehydrogenase increased among males.

The phase IV clinical study analyzes what interactions people have when they take Sotalol hydrochloride and Toprol-xl. It is created by eHealthMe based on reports of 17 people who take the same drugs from the FDA, and is updated regularly.

What is Sotalol hydrochloride?

Sotalol hydrochloride has active ingredients of sotalol hydrochloride. It is often used in atrial fibrillation/flutter. eHealthMe is studying from 3,643 Sotalol hydrochloride users. Check the latest studies of Sotalol hydrochloride.

What is Toprol-xl?

Toprol-xl has active ingredients of metoprolol succinate. It is often used in high blood pressure. eHealthMe is studying from 40,636 Toprol-xl users. Check the latest studies of Toprol-xl.

On Jul, 20, 2026

17 people who take Sotalol hydrochloride and Toprol-xl together, and have interactions are studied.

Sotalol hydrochloride and Toprol-xl drug interactions.

What are the common drug interactions of Sotalol Hydrochloride and Toprol-Xl, by gender? *:

female:

Asthenia (weakness)
Blood creatinine increased
Cardiac valve disease (heart valve disease)
Cardioversion
Ejection fraction decreased (systolic heart failure)
Electrocardiogram qt prolonged
Heart valve incompetence (heart's valves do not work correctly)
Hypotension (abnormally low blood pressure)
Malaise (a feeling of general discomfort or uneasiness)
Palpitations (feelings or sensations that your heart is pounding or racing)

male:

Blood lactate dehydrogenase increased
Bundle branch block right (absence of transmission of electric impulses from the atrioventricular (av) bundle of his to the right ventricle)
Blood iron increased
Blood uric acid increased
Cardiac disorder
Cardiac failure congestive
Cardiac fibrillation (uncontrolled muscle contraction of heart)
Cardiovascular disorder (heart diseases)
Carotid artery disease
Coronary artery bypass

What are the common drug interactions of Sotalol Hydrochloride and Toprol-Xl, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Cardiac fibrillation (uncontrolled muscle contraction of heart)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Weight increased

50-59:

n/a

60+:

Ventricular extrasystoles (premature cardiac contraction)
Electrocardiogram qt prolonged
Cardioversion
Ejection fraction decreased (systolic heart failure)
Heart valve incompetence (heart's valves do not work correctly)
Hypotension (abnormally low blood pressure)
Malaise (a feeling of general discomfort or uneasiness)
Palpitations (feelings or sensations that your heart is pounding or racing)
Syncope (loss of consciousness with an inability to maintain postural tone)
Torsade de pointes (a abnormal heart rate with abnormal beating pattern)

What are the existing conditions these people have? *

Lung Cancer - Non-Small Cell (lung cancer): 3 people, 17.65%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 1 person, 5.88%
Renal Cell Carcinoma Stage Unspecified (kidney cancer in unknown stage): 1 person, 5.88%
Pulmonary Hypertension (increase in blood pressure in the lung artery): 1 person, 5.88%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 1 person, 5.88%
High Blood Cholesterol: 1 person, 5.88%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 1 person, 5.88%
Bipolar Disorder (mood disorder): 1 person, 5.88%

* Approximation only. Some reports may have incomplete information.

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