Sovaldi and Prozac drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Sovaldi (sofosbuvir) and Prozac (fluoxetine hydrochloride). Common drug interactions include fatigue among females and fatigue among males.

The phase IV clinical study analyzes what interactions people have when they take Sovaldi and Prozac. It is created by eHealthMe based on reports of 35 people who take the same drugs from the FDA, and is updated regularly.

What is Sovaldi?

Sovaldi has active ingredients of sofosbuvir. eHealthMe is studying from 12,697 Sovaldi users. Check the latest studies of Sovaldi.

What is Prozac?

Prozac has active ingredients of fluoxetine hydrochloride. It is often used in depression. eHealthMe is studying from 82,974 Prozac users. Check the latest studies of Prozac.

On Oct, 27, 2025

35 people who take Sovaldi and Prozac together, and have interactions are studied.

What are the common drug interactions of Sovaldi and Prozac, by gender? *:

female:

Fatigue (feeling of tiredness)
Dizziness
Headache (pain in head)
Nausea (feeling of having an urge to vomit)
Ammonia increased
Anaemia (lack of blood)
Constipation
Memory impairment
Muscular weakness (muscle weakness)
Pain

male:

Fatigue (feeling of tiredness)
Headache (pain in head)
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Mesenteric vein thrombosis (blood clot in mesenteric vein)
Serotonin syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time)
White blood cell count decreased
Abdominal pain
Abnormal behaviour
Aggression
Agitation (state of anxiety or nervous excitement)

What are the common drug interactions of Sovaldi and Prozac, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Pain
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Abdominal pain
Urinary tract infection

30-39:

Fatigue (feeling of tiredness)
Anaemia (lack of blood)
Headache (pain in head)
Injection site pruritus (severe itching at injection site)
Injection site rash
Leukopenia (less number of white blood cells in blood)
Nausea (feeling of having an urge to vomit)
Suicidal ideation
Thrombocytopenia (decrease of platelets in blood)
Memory impairment

40-49:

Headache (pain in head)
Anaemia (lack of blood)
Constipation
Dizziness
Fatigue (feeling of tiredness)
Rash generalised (rash on most of body parts)

50-59:

Completed suicide (act of taking one's own life)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Dizziness
Epistaxis (bleed from the nose)
Haemoglobin decreased
Head discomfort
Headache (pain in head)
Muscular weakness (muscle weakness)
Myalgia (muscle pain)
Serotonin syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time)

60+:

Fatigue (feeling of tiredness)
White blood cell count decreased
Epistaxis (bleed from the nose)
Hepatic cirrhosis (chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue)
Insomnia (sleeplessness)
Mesenteric vein thrombosis (blood clot in mesenteric vein)
Mouth haemorrhage (bleeding from mouth)
Portal vein thrombosis (venous thrombosis affecting the hepatic portal vein)

What are the existing conditions these people have? *

Hepatitis C: 19 people, 54.29%
Sleep Disorder: 5 people, 14.29%
Pain: 5 people, 14.29%
Stress And Anxiety: 3 people, 8.57%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 3 people, 8.57%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 3 people, 8.57%
Bipolar Ii Disorder (characterized by at least one episode of hypomania and at least one episode of major depression): 3 people, 8.57%

* Approximation only. Some reports may have incomplete information.

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