Sovaldi and Zofran drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Sovaldi (sofosbuvir) and Zofran (ondansetron hydrochloride). Common drug interactions include sleep apnoea syndrome among females and headache among males.

The phase IV clinical study analyzes what interactions people have when they take Sovaldi and Zofran. It is created by eHealthMe based on reports of 37 people who take the same drugs from the FDA, and is updated regularly.

What is Sovaldi?

Sovaldi has active ingredients of sofosbuvir. eHealthMe is studying from 12,697 Sovaldi users. Check the latest studies of Sovaldi.

What is Zofran?

Zofran has active ingredients of ondansetron hydrochloride. It is often used in nausea. eHealthMe is studying from 94,987 Zofran users. Check the latest studies of Zofran.

On Jul, 14, 2026

37 people who take Sovaldi and Zofran together, and have interactions are studied.

What are the common drug interactions of Sovaldi and Zofran, by gender? *:

female:

Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Abdominal pain
Abdominal pain upper
Arthralgia (joint pain)
Atrioventricular block second degree (heart block second degree)
Confusional state
Dehydration (dryness resulting from the removal of water)
Dysgeusia (disorder of the sense of taste)
Dyspnoea (difficult or laboured respiration)
Electrocardiogram qt prolonged

male:

Headache (pain in head)
Abdominal distension
Dyspnoea (difficult or laboured respiration)
Injection site rash
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Pruritus (severe itching of the skin)
Suicidal ideation
Thrombocytopenia (decrease of platelets in blood)
Abdominal pain
Abdominal pain upper

What are the common drug interactions of Sovaldi and Zofran, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Pain
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)

30-39:

Anaemia (lack of blood)
Depression
Fatigue (feeling of tiredness)
Headache (pain in head)
Injection site pruritus (severe itching at injection site)
Injection site rash
Leukopenia (less number of white blood cells in blood)
Suicidal ideation
Thrombocytopenia (decrease of platelets in blood)
Abdominal pain

40-49:

Pyrexia (fever)
Autoimmune hepatitis
Cough
Decreased appetite
Diarrhoea
Drug-induced liver injury (diseases of the liver that are caused by physician-prescribed medications)
Dysuria (painful or difficult urination)
Fatigue (feeling of tiredness)
Jaundice (a yellowish pigmentation of the skin, the conjunctival membranes)
Ocular icterus (presence of jaundice seen in the sclera of the eye)

50-59:

Anaemia (lack of blood)
Angina pectoris (chest pain due to ischemia of the heart muscle)
Blood bilirubin increased
Blood iron increased
Cardiac disorder
Chest pain
Chronic kidney disease
Drug ineffective
Dysgeusia (disorder of the sense of taste)
Dyspnoea (difficult or laboured respiration)

60+:

Abdominal pain upper
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Ammonia increased
Aphagia (inability or refusal to swallow)
Appetite disorder (abnormal eating habits)
Arthralgia (joint pain)
Asthenia (weakness)
Bone pain
Confusional state
Dry skin

What are the existing conditions these people have? *

Hepatitis C: 25 people, 67.57%
Depression: 6 people, 16.22%
Urination - Painful: 4 people, 10.81%
Stress And Anxiety: 4 people, 10.81%
Pain: 4 people, 10.81%
Autoimmune Hepatitis: 4 people, 10.81%
Sleep Disorder: 3 people, 8.11%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 3 people, 8.11%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 3 people, 8.11%
Bipolar Ii Disorder (characterized by at least one episode of hypomania and at least one episode of major depression): 3 people, 8.11%

* Approximation only. Some reports may have incomplete information.

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