Spiriva respimat and Ativan drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Spiriva respimat (tiotropium bromide) and Ativan (lorazepam). Common drug interactions include speech disorder among females and apathy among males.

The phase IV clinical study analyzes what interactions people have when they take Spiriva respimat and Ativan. It is created by eHealthMe based on reports of 54 people who take the same drugs from the FDA, and is updated regularly.

What is Spiriva respimat?

Spiriva respimat has active ingredients of tiotropium bromide. It is often used in chronic obstructive pulmonary disease. eHealthMe is studying from 9,788 Spiriva respimat users. Check the latest studies of Spiriva respimat.

What is Ativan?

Ativan has active ingredients of lorazepam. It is often used in stress and anxiety. eHealthMe is studying from 78,506 Ativan users. Check the latest studies of Ativan.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 31, 2026

54 people who take Spiriva respimat and Ativan together, and have interactions are studied.

Spiriva respimat and Ativan drug interactions.

What are the common drug interactions of Spiriva Respimat and Ativan, by gender? *:

female:

Speech disorder
Urinary tract infection
Visual impairment
Application site discolouration
Asthmatic crisis
Cd4 lymphocytes decreased
Cerebrospinal fluid leakage
Chronic kidney disease
Cough
Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)

male:

Apathy
Diarrhoea
Haemorrhagic anaemia (anaemia due to excessive bleeding)
Lethargy (tiredness)
Adverse drug reaction
Aggression
Agitation (state of anxiety or nervous excitement)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Asthenia (weakness)
Balance disorder

What are the common drug interactions of Spiriva Respimat and Ativan, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Blood pressure increased
Delusion (a false belief or opinion)
Encephalitis (inflammation of the brain)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Headache (pain in head)
Muscle spasms (muscle contraction)
Pain
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Urinary incontinence (inability to control the flow of urine and involuntary urination)
Vertigo

20-29:

Device failure
Drug ineffective
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)

30-39:

Abdominal infection
Anaphylactic reaction (serious allergic reaction)
Back disorder
Cardiac failure
Dyspnoea (difficult or laboured respiration)
Fall
Gait disturbance
Monoplegia (a paralysis of a single limb)
Urinary tract infection

40-49:

Adverse drug reaction
Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection)
Infusion site bruising
Infusion site pain
Pneumonia
Post procedural discharge
Sinusitis (inflammation of sinus)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Disability
Dyspnoea (difficult or laboured respiration)

50-59:

Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Diplopia (double vision)
Dysphagia (a condition in which swallowing is difficult or painful)
Infusion site bruising
Speech disorder
Visual impairment
Herpes zoster
Injection site bruising
Adverse drug reaction
Application site discolouration

60+:

Psychotic disorder
Apathy
Rash erythematous (redness of the skin)
Chronic kidney disease
Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)
Dysphonia (speech disorder attributable to a disorder of phonation)
Fall
Gallbladder disorder
Gastritis (inflammation of stomach)
Haemorrhagic anaemia (anaemia due to excessive bleeding)

What are the existing conditions these people have? *

Immunodeficiency: 9 people, 16.67%
Immunodeficiency Common Variable: 8 people, 14.81%
Asthma: 8 people, 14.81%
Type 2 Diabetes: 4 people, 7.41%
Multiple Myeloma (cancer of the plasma cells): 4 people, 7.41%
High Blood Pressure: 4 people, 7.41%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 4 people, 7.41%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 3 people, 5.56%
Insomnia (sleeplessness): 3 people, 5.56%
Helicobacter Infection (helicobacter pylori (h. pylori) infects stomach): 3 people, 5.56%

* Approximation only. Some reports may have incomplete information.

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