Spiriva respimat and Ofev drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Spiriva respimat (tiotropium bromide) and Ofev (nintedanib esylate). Common drug interactions include haematochezia among females and diarrhoea among males.

The phase IV clinical study analyzes what interactions people have when they take Spiriva respimat and Ofev. It is created by eHealthMe based on reports of 41 people who take the same drugs from the FDA, and is updated regularly.

What is Spiriva respimat?

Spiriva respimat has active ingredients of tiotropium bromide. It is often used in chronic obstructive pulmonary disease. eHealthMe is studying from 9,788 Spiriva respimat users. Check the latest studies of Spiriva respimat.

What is Ofev?

Ofev has active ingredients of nintedanib esylate. eHealthMe is studying from 24,791 Ofev users. Check the latest studies of Ofev.

On Jul, 16, 2026

41 people who take Spiriva respimat and Ofev together, and have interactions are studied.

Spiriva respimat and Ofev drug interactions.

What are the common drug interactions of Spiriva Respimat and Ofev, by gender? *:

female:

Haematochezia (passage of stools containing blood)
Stress
Abdominal pain upper
Ageusia (loss of taste functions of the tongue)
Alopecia (absence of hair from areas of the body)
Chronic respiratory failure
Drooling (drop saliva uncontrollably from the mouth)
Dry mouth
Dyspepsia (indigestion)
Fatigue (feeling of tiredness)

male:

Diarrhoea
Epistaxis (bleed from the nose)
Oxygen saturation increased
Productive cough
Rectal fissure (painful condition in which a cut or tear occurs in the anus)
Renal cyst (kidney cyst)
Blood pressure increased
Pneumonia
Nausea (feeling of having an urge to vomit)
Dyspnoea exertional (breathlessness or shortness of breath)

What are the common drug interactions of Spiriva Respimat and Ofev, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

n/a

60+:

Diarrhoea
Constipation
Blood glucose increased
Blood pressure fluctuation
Dyspnoea exertional (breathlessness or shortness of breath)
Eye haemorrhage (bleeding in the eye)
Facial paralysis (loss of function of face muscle)
Gait disturbance
Hepatic enzyme increased
Hypertension (high blood pressure)

What are the existing conditions these people have? *

Idiopathic Pulmonary Fibrosis (chronic lung disease): 25 people, 60.98%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 10 people, 24.39%
Wheezing (a high-pitched whistling sound made while you breath): 5 people, 12.20%
High Blood Pressure: 5 people, 12.20%
Interstitial Lung Disease: 4 people, 9.76%
Chest Pain: 3 people, 7.32%
Asthma: 3 people, 7.32%

* Approximation only. Some reports may have incomplete information.

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