Spiriva and Flavin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Spiriva (tiotropium bromide monohydrate) and Flavin (riboflavin (vitamin b2)). Common drug interactions include dyspnoea among females and deafness among males.

The phase IV clinical study analyzes what interactions people have when they take Spiriva and Flavin. It is created by eHealthMe based on reports of 27 people who take the same drugs from the FDA, and is updated regularly.

What is Spiriva?

Spiriva has active ingredients of tiotropium bromide monohydrate. It is often used in chronic obstructive pulmonary disease. eHealthMe is studying from 156,666 Spiriva users. Check the latest studies of Spiriva.

What is Flavin?

Flavin has active ingredients of riboflavin (vitamin b2). eHealthMe is studying from 2,870 Flavin users. Check the latest studies of Flavin.



On Jul, 11, 2026

27 people who take Spiriva and Flavin together, and have interactions are studied.

Spiriva and Flavin drug interactions.

What are the common drug interactions of Spiriva and Flavin, by gender? *:

female:

  1. Dyspnoea (difficult or laboured respiration)
  2. Hypersensitivity
  3. Impaired gastric emptying
  4. Pain
  5. Vomiting
  6. Forced expiratory volume decreased (decreased lung expired air volume)
  7. Gastrointestinal disorder (functional problems of gastrointestinal tract)
  8. General physical health deterioration (weak health status)
  9. Hyperchlorhydria (gastric acid levels are higher in stomach)
  10. Malaise (a feeling of general discomfort or uneasiness)

male:

  1. Deafness
  2. Drug ineffective
  3. Injection site erythema (redness at injection site)
  4. Injection site pain
  5. Injection site swelling
  6. Pulmonary arterial hypertension (high blood pressure in the arteries of lungs)
  7. Renal failure (kidney dysfunction)
  8. Seizure (abnormal excessive or synchronous neuronal activity in the brain)
  9. Transient ischaemic attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow))
  10. Urticaria (rash of round, red welts on the skin that itch intensely)

What are the common drug interactions of Spiriva and Flavin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

  1. Drug ineffective
  2. Injection site pain

40-49:

  1. Dyspnoea (difficult or laboured respiration)
  2. Forced expiratory volume decreased (decreased lung expired air volume)
  3. Gastrointestinal disorder (functional problems of gastrointestinal tract)
  4. General physical health deterioration (weak health status)
  5. Hyperchlorhydria (gastric acid levels are higher in stomach)
  6. Impaired gastric emptying
  7. Malaise (a feeling of general discomfort or uneasiness)
  8. Obstructive airways disorder (a progressive disease that makes it hard to breathe)
  9. Osteonecrosis (death of bone)
  10. Pain

50-59:

n/a

60+:

  1. Deafness
  2. Drug ineffective
  3. Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
  4. Confusional state
  5. Cough
  6. Disease complication
  7. Disease progression
  8. Dysarthria (speech disorder)
  9. Dyspnoea (difficult or laboured respiration)
  10. Epistaxis (bleed from the nose)

What are the existing conditions these people have? *

  1. Asthma: 6 people, 22.22%
  2. Pulmonary Hypertension (increase in blood pressure in the lung artery): 3 people, 11.11%
  3. Migraine (headache): 3 people, 11.11%
  4. Pseudomonas Infection (pseudomonas infection is caused by a bacterium, pseudomonas aeruginosa): 2 people, 7.41%
  5. Immunodeficiency Common Variable: 2 people, 7.41%
  6. Immune System Disorder: 2 people, 7.41%
  7. Cystic Fibrosis (disease of the secretary glands): 2 people, 7.41%

* Approximation only. Some reports may have incomplete information.

Do you take Spiriva and Flavin?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Spiriva and Flavin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Spiriva:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Flavin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Spiriva and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Flavin and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on tiotropium bromide monohydrate and riboflavin (vitamin b2) (the active ingredients of Spiriva and Flavin, respectively), and Spiriva and Flavin (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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