Spiriva and Flecainide acetate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Spiriva (tiotropium bromide monohydrate) and Flecainide acetate (flecainide acetate). Common drug interactions include localised infection among females and dyspnoea among males.

The phase IV clinical study analyzes what interactions people have when they take Spiriva and Flecainide acetate. It is created by eHealthMe based on reports of 91 people who take the same drugs from the FDA, and is updated regularly.

What is Spiriva?

Spiriva has active ingredients of tiotropium bromide monohydrate. It is often used in chronic obstructive pulmonary disease. eHealthMe is studying from 156,666 Spiriva users. Check the latest studies of Spiriva.

What is Flecainide acetate?

Flecainide acetate has active ingredients of flecainide acetate. It is often used in atrial fibrillation/flutter. eHealthMe is studying from 7,176 Flecainide acetate users. Check the latest studies of Flecainide acetate.



On Jul, 26, 2026

91 people who take Spiriva and Flecainide acetate together, and have interactions are studied.

Spiriva and Flecainide acetate drug interactions.

What are the common drug interactions of Spiriva and Flecainide Acetate, by gender? *:

female:

  1. Localised infection (infection at the single location)
  2. Lymphoedema (localized fluid retention and tissue swelling)
  3. Pericardial effusion (fluid around the heart)
  4. Pneumonia fungal
  5. Pseudomonas infection (pseudomonas infection is caused by a bacterium, pseudomonas aeruginosa)
  6. Pulmonary vascular disorder
  7. Rib fracture
  8. Somnambulism (sleep walking)
  9. Thyroid cyst
  10. Vomiting

male:

  1. Dyspnoea (difficult or laboured respiration)
  2. Cough
  3. Drug resistance (reduction in effectiveness of a drug)
  4. Prostate infection
  5. Fatigue (feeling of tiredness)
  6. Migraine (headache)
  7. Pseudomonas infection (pseudomonas infection is caused by a bacterium, pseudomonas aeruginosa)
  8. Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
  9. Dizziness
  10. Cataract (clouding of the lens inside the eye)

What are the common drug interactions of Spiriva and Flecainide Acetate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

  1. Migraine (headache)
  2. Pruritus (severe itching of the skin)
  3. Urticaria (rash of round, red welts on the skin that itch intensely)
  4. Vomiting

50-59:

  1. Bladder discomfort
  2. Blood urine present
  3. Chills (felling of cold)
  4. Dizziness
  5. Dysstasia (difficulty in standing)
  6. Feeling cold
  7. Flushing (the warm, red condition of human skin)
  8. Joint swelling
  9. Nephrolithiasis (calculi in the kidneys)
  10. Oedema peripheral (superficial swelling)

60+:

  1. Dyspnoea (difficult or laboured respiration)
  2. Headache (pain in head)
  3. Pharyngitis streptococcal (inflammation of the pharynx caused by infection from. streptococcus)
  4. Infusion site pain
  5. Peripheral swelling
  6. Pneumonia
  7. Urinary tract infection
  8. Drug resistance (reduction in effectiveness of a drug)
  9. Abdominal hernia
  10. Abdominal pain upper

What are the existing conditions these people have? *

  1. High Blood Pressure: 13 people, 14.29%
  2. Immunodeficiency Common Variable: 12 people, 13.19%
  3. High Blood Cholesterol: 12 people, 13.19%
  4. Asthma: 9 people, 9.89%
  5. Arrhythmias (irregular heartbeat): 7 people, 7.69%
  6. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 6.59%
  7. Diabetes: 6 people, 6.59%
  8. Chest Pain: 5 people, 5.49%

* Approximation only. Some reports may have incomplete information.

Do you take Spiriva and Flecainide acetate?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Spiriva and Flecainide acetate:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Spiriva:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Flecainide acetate:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Spiriva and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Flecainide acetate and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on tiotropium bromide monohydrate and flecainide acetate (the active ingredients of Spiriva and Flecainide acetate, respectively), and Spiriva and Flecainide acetate (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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