Spiriva and Maxipime drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Spiriva (tiotropium bromide monohydrate) and Maxipime (cefepime hydrochloride). Common drug interactions include pyrexia among females and platelet count decreased among males.

The phase IV clinical study analyzes what interactions people have when they take Spiriva and Maxipime. It is created by eHealthMe based on reports of 31 people who take the same drugs from the FDA, and is updated regularly.

What is Spiriva?

Spiriva has active ingredients of tiotropium bromide monohydrate. It is often used in chronic obstructive pulmonary disease. eHealthMe is studying from 156,666 Spiriva users. Check the latest studies of Spiriva.

What is Maxipime?

Maxipime has active ingredients of cefepime hydrochloride. eHealthMe is studying from 4,279 Maxipime users. Check the latest studies of Maxipime.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

31 people who take Spiriva and Maxipime together, and have interactions are studied.

What are the common drug interactions of Spiriva and Maxipime, by gender? *:

female:

Pyrexia (fever)
Respiratory rate increased (excess breathing rate/min)
Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down)
Viral upper respiratory tract infection
Vision blurred
Blood creatinine increased
Blood urea increased
Carbon monoxide poisoning
Death
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)

male:

Platelet count decreased
Neutrophil count decreased (less than normal number of neutrophil a type of blood cell)
Febrile neutropenia (fever with reduced white blood cells)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Hyperchloraemia (an excess of chlorides in the blood)
Hypernatraemia (an abnormally high plasma concentration of sodium ions)
Hyperphosphataemia (electrolyte disturbance in which there is an abnormally elevated level of phosphate in the blood)
Hypokalaemia (low potassium)
Neutropenia (an abnormally low number of neutrophils)
Renal disorder (kidney disease)

What are the common drug interactions of Spiriva and Maxipime, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Acute sinusitis
Blood glucose increased
Infective pulmonary exacerbation of cystic fibrosis (severe infective lung disease with production of abnormally thick mucus)

20-29:

n/a

30-39:

n/a

40-49:

Abdominal pain

50-59:

Neutropenia (an abnormally low number of neutrophils)
Pancreatitis acute (sudden inflammation of pancreas)
Pneumonia
Sinus disorder (disease of sinus)
Bladder prolapse (bulging of one or more of the pelvic organs into the vagina)
Body temperature decreased
Breath sounds
Fatigue (feeling of tiredness)
Hypoventilation (too shallow or too slow breathing, which does not meet the needs of the body)
Infection susceptibility increased

60+:

Platelet count decreased
Neutrophil count decreased (less than normal number of neutrophil a type of blood cell)
Febrile neutropenia (fever with reduced white blood cells)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Hyperchloraemia (an excess of chlorides in the blood)
Hypernatraemia (an abnormally high plasma concentration of sodium ions)
Hyperphosphataemia (electrolyte disturbance in which there is an abnormally elevated level of phosphate in the blood)
Hypokalaemia (low potassium)
Neutropenia (an abnormally low number of neutrophils)
Renal disorder (kidney disease)

What are the existing conditions these people have? *

Myelodysplastic Syndrome (a group of conditions that occur when the blood-forming cells in the bone marrow are damaged): 5 people, 16.13%
Pain: 4 people, 12.90%
Multiple Myeloma (cancer of the plasma cells): 4 people, 12.90%
Bronchopulmonary Aspergillosis (lung disorder caused by aspergillus fungi): 3 people, 9.68%
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection): 3 people, 9.68%
Pneumonia: 2 people, 6.45%
Nausea (feeling of having an urge to vomit): 2 people, 6.45%
High Blood Pressure: 2 people, 6.45%
Fungal Infection: 2 people, 6.45%

* Approximation only. Some reports may have incomplete information.

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