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Spiriva and Minivelle drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Spiriva (tiotropium bromide monohydrate) and Minivelle (estradiol). Common drug interactions include headache among females.

The phase IV clinical study analyzes what interactions people have when they take Spiriva and Minivelle. It is created by eHealthMe based on reports of 18 people who take the same drugs from the FDA, and is updated regularly.

What is Spiriva?

Spiriva has active ingredients of tiotropium bromide monohydrate. It is often used in chronic obstructive pulmonary disease. eHealthMe is studying from 156,666 Spiriva users. Check the latest studies of Spiriva.

What is Minivelle?

Minivelle has active ingredients of estradiol. eHealthMe is studying from 3,480 Minivelle users. Check the latest studies of Minivelle.

On Aug, 10, 2026

18 people who take Spiriva and Minivelle together, and have interactions are studied.

Spiriva and Minivelle drug interactions.

What are the common drug interactions of Spiriva and Minivelle, by gender? *:

female:

  1. Headache (pain in head)
  2. Fatigue (feeling of tiredness)
  3. Neoplasm malignant (cancer tumour)
  4. Basal cell carcinoma (a skin cancer, it rarely metastasizes or kills)
  5. Blood pressure increased
  6. Bone pain
  7. Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
  8. Death
  9. Diarrhoea
  10. Drug hypersensitivity

male:

n/a

What are the common drug interactions of Spiriva and Minivelle, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

  1. Headache (pain in head)
  2. Drug hypersensitivity
  3. Impaired work ability
  4. Influenza
  5. Malaise (a feeling of general discomfort or uneasiness)
  6. Osteoarthritis (a joint disease caused by cartilage loss in a joint)
  7. Platelet disorder
  8. Post-traumatic stress disorder
  9. Pyrexia (fever)
  10. Renal disorder (kidney disease)

60+:

  1. Blood pressure increased

What are the existing conditions these people have? *

  1. Asthma: 6 people, 33.33%
  2. Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 5 people, 27.78%
  3. Essential Thrombocythaemia (chronic blood cancer): 5 people, 27.78%
  4. Immune System Disorder: 5 people, 27.78%
  5. Cataplexy (loss of muscle tone accompanied by full conscious awareness): 4 people, 22.22%
  6. Thrombocytosis: 4 people, 22.22%
  7. Fluid Retention (an abnormal accumulation of fluid in the blood): 1 person, 5.56%
  8. Diarrhea: 1 person, 5.56%
  9. Emphysema (chronic respiratory disease - over inflation of the air sacs (alveoli) in the lungs): 1 person, 5.56%
  10. Fibromyalgia (a long-term condition which causes pain all over the body): 1 person, 5.56%

* Approximation only. Some reports may have incomplete information.

Do you take Spiriva and Minivelle?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Spiriva and Minivelle:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Spiriva:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Minivelle:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Spiriva and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Minivelle and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on tiotropium bromide monohydrate and estradiol (the active ingredients of Spiriva and Minivelle, respectively), and Spiriva and Minivelle (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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