Spiriva and Nyquil drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Spiriva (tiotropium bromide monohydrate) and Nyquil (acetaminophen / dextromethorphan / doxylamine / pseudoephedrine). Common drug interactions include fall among females and nasopharyngitis among males.

The phase IV clinical study analyzes what interactions people have when they take Spiriva and Nyquil. It is created by eHealthMe based on reports of 27 people who take the same drugs from the FDA, and is updated regularly.

What is Spiriva?

Spiriva has active ingredients of tiotropium bromide monohydrate. It is often used in chronic obstructive pulmonary disease. eHealthMe is studying from 156,666 Spiriva users. Check the latest studies of Spiriva.

What is Nyquil?

Nyquil has active ingredients of acetaminophen / dextromethorphan / doxylamine / pseudoephedrine. It is often used in cold symptoms. eHealthMe is studying from 2,240 Nyquil users. Check the latest studies of Nyquil.

On Jul, 28, 2026

27 people who take Spiriva and Nyquil together, and have interactions are studied.

What are the common drug interactions of Spiriva and Nyquil, by gender? *:

female:

Fall
Hip fracture
Arthralgia (joint pain)
Tinnitus (a ringing in the ears)
Fatigue (feeling of tiredness)
Alopecia (absence of hair from areas of the body)
Anaphylactic reaction (serious allergic reaction)
Upper-airway cough syndrome
Urinary tract infection
Abdominal pain

male:

Nasopharyngitis (inflammation of the nasopharynx)
Lower respiratory tract infection
Headache (pain in head)
Hypertension (high blood pressure)
Influenza
Infusion related reaction
Poor venous access
Sinusitis (inflammation of sinus)
Spinal fracture (fracture in one of vertebrae)
Toothache (tooth pain)

What are the common drug interactions of Spiriva and Nyquil, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Nausea (feeling of having an urge to vomit)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Arthralgia (joint pain)
Back pain
Bone neoplasm (tumour of bone)
Cardiac failure congestive
Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)
Catheter site pain
Chest pain
Contusion (a type of hematoma of tissue in which capillaries)

60+:

Anaphylactic reaction (serious allergic reaction)
Fatigue (feeling of tiredness)
Upper-airway cough syndrome
Death
Fall
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Headache (pain in head)
Nasopharyngitis (inflammation of the nasopharynx)
Sinusitis (inflammation of sinus)
Spinal fracture (fracture in one of vertebrae)

What are the existing conditions these people have? *

Pain: 4 people, 14.81%
Speech Disorder: 3 people, 11.11%
Sleep Disorder: 3 people, 11.11%
Muscle Spasms (muscle contraction): 3 people, 11.11%
Migraine (headache): 3 people, 11.11%
Joint Stiffness: 3 people, 11.11%
Ill-Defined Disorder: 3 people, 11.11%
Hypersensitivity: 3 people, 11.11%
Hair Growth Abnormal: 3 people, 11.11%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 11.11%

* Approximation only. Some reports may have incomplete information.

Do you take Spiriva and Nyquil?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously