Spiriva and Rapaflo drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Spiriva (tiotropium bromide monohydrate) and Rapaflo (silodosin). Common drug interactions include anorectal disorder among females and pneumonia among males.

The phase IV clinical study analyzes what interactions people have when they take Spiriva and Rapaflo. It is created by eHealthMe based on reports of 72 people who take the same drugs from the FDA, and is updated regularly.

What is Spiriva?

Spiriva has active ingredients of tiotropium bromide monohydrate. It is often used in chronic obstructive pulmonary disease. eHealthMe is studying from 156,666 Spiriva users. Check the latest studies of Spiriva.

What is Rapaflo?

Rapaflo has active ingredients of silodosin. It is often used in prostate examination abnormal. eHealthMe is studying from 3,929 Rapaflo users. Check the latest studies of Rapaflo.

On Jul, 15, 2026

72 people who take Spiriva and Rapaflo together, and have interactions are studied.

What are the common drug interactions of Spiriva and Rapaflo, by gender? *:

female:

Anorectal disorder
Chills (felling of cold)
Dizziness
Dysstasia (difficulty in standing)
Ear disorder
Faecal incontinence (a lack of control over passing stool)
Infection
Palpitations (feelings or sensations that your heart is pounding or racing)
Swelling face
Tooth abscess (pus formation in tooth)

male:

Pneumonia
Dyspnoea (difficult or laboured respiration)
Dysphagia (a condition in which swallowing is difficult or painful)
Fatigue (feeling of tiredness)
Hypersensitivity
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)
Rash maculo-papular (red area on the skin that is covered with small confluent bumps)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Fluid retention (an abnormal accumulation of fluid in the blood)
Death

What are the common drug interactions of Spiriva and Rapaflo, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Dizziness
Dysstasia (difficulty in standing)
Faecal incontinence (a lack of control over passing stool)
Palpitations (feelings or sensations that your heart is pounding or racing)
Visual impairment

40-49:

Angina pectoris (chest pain due to ischemia of the heart muscle)
Atrioventricular block second degree (heart block second degree)
Chest pain
Hypertension (high blood pressure)
Lung infection
Nausea (feeling of having an urge to vomit)
Nephrolithiasis (calculi in the kidneys)
Pneumonia
Pyelonephritis (inflammation of kidney caused by bacteria)
Sepsis (a severe blood infection that can lead to organ failure and death)

50-59:

Death
Joint injury
Pneumonia
Skeletal injury (bone and supporting muscle injury)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Ankle fracture
Anxiety
Balance disorder
Emotional distress
Multiple fractures

60+:

Pneumonia
Dyspnoea (difficult or laboured respiration)
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)
Rash maculo-papular (red area on the skin that is covered with small confluent bumps)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Fluid retention (an abnormal accumulation of fluid in the blood)
Balance disorder
Fall
Fatigue (feeling of tiredness)
Laceration (tearing of soft body tissue)

What are the existing conditions these people have? *

Asthma: 9 people, 12.50%
Wound Infection: 7 people, 9.72%
Dyspnea (difficult or laboured breathing): 6 people, 8.33%
Osteoporosis (bones weak and more likely to break): 5 people, 6.94%
Multiple Myeloma (cancer of the plasma cells): 5 people, 6.94%
Prostatomegaly (enlargement of the prostate): 4 people, 5.56%

* Approximation only. Some reports may have incomplete information.

Do you take Spiriva and Rapaflo?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously