Spiriva and Triamterene drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Spiriva (tiotropium bromide monohydrate) and Triamterene (triamterene). Common drug interactions include hypoxia among females and alopecia among males.

The phase IV clinical study analyzes what interactions people have when they take Spiriva and Triamterene. It is created by eHealthMe based on reports of 33 people who take the same drugs from the FDA, and is updated regularly.

What is Spiriva?

Spiriva has active ingredients of tiotropium bromide monohydrate. It is often used in chronic obstructive pulmonary disease. eHealthMe is studying from 156,666 Spiriva users. Check the latest studies of Spiriva.

What is Triamterene?

Triamterene has active ingredients of triamterene. eHealthMe is studying from 2,210 Triamterene users. Check the latest studies of Triamterene.



On Jul, 14, 2026

33 people who take Spiriva and Triamterene together, and have interactions are studied.

Spiriva and Triamterene drug interactions.

What are the common drug interactions of Spiriva and Triamterene, by gender? *:

female:

  1. Hypoxia (low oxygen in tissues)
  2. Influenza like illness
  3. Iron deficiency anaemia
  4. Muscular weakness (muscle weakness)
  5. Nasopharyngitis (inflammation of the nasopharynx)
  6. Nausea (feeling of having an urge to vomit)
  7. Osteoarthritis (a joint disease caused by cartilage loss in a joint)
  8. Pain in extremity
  9. Pain in jaw
  10. Pericardial effusion (fluid around the heart)

male:

  1. Alopecia (absence of hair from areas of the body)
  2. Arthralgia (joint pain)
  3. Blood potassium decreased
  4. Brain natriuretic peptide increased
  5. Calcium ionised decreased
  6. Chest discomfort
  7. Complement factor decreased
  8. Deafness
  9. Diaphragm muscle weakness
  10. Diaphragmatic disorder

What are the common drug interactions of Spiriva and Triamterene, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

  1. Anhedonia (inability to experience pleasure from activities usually found enjoyable)
  2. Ankle fracture
  3. Anxiety
  4. Bone density decreased
  5. Depression
  6. Emotional distress
  7. Hand fracture
  8. Muscular weakness (muscle weakness)
  9. Osteoporosis (bones weak and more likely to break)
  10. Pain

50-59:

  1. Calcium ionised decreased
  2. Chest discomfort
  3. Complement factor decreased
  4. Cough
  5. Deafness
  6. Diaphragm muscle weakness
  7. Diaphragmatic disorder
  8. Drug hypersensitivity
  9. Dyspnoea (difficult or laboured respiration)
  10. Food allergy

60+:

  1. Dyspnoea (difficult or laboured respiration)
  2. Pneumonia
  3. Atelectasis (partial or complete collapse of the lung)
  4. Bronchiectasis (abnormal widening of the bronchi or their branches, causing a risk of infection)
  5. Contusion (a type of hematoma of tissue in which capillaries)
  6. Cough
  7. Deafness unilateral
  8. Decreased appetite
  9. Diarrhoea
  10. Drug hypersensitivity

What are the existing conditions these people have? *

  1. Asthma: 5 people, 15.15%
  2. Constipation: 4 people, 12.12%
  3. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 12.12%
  4. Blood Pressure Abnormal: 3 people, 9.09%
  5. Pulmonary Hypertension (increase in blood pressure in the lung artery): 3 people, 9.09%
  6. Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 3 people, 9.09%
  7. Hiv Infection: 3 people, 9.09%
  8. Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 2 people, 6.06%
  9. Cardiac Disorder: 2 people, 6.06%
  10. Depression: 2 people, 6.06%

* Approximation only. Some reports may have incomplete information.

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Spiriva and Triamterene:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Spiriva:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Triamterene:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Spiriva and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Triamterene and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on tiotropium bromide monohydrate and triamterene (the active ingredients of Spiriva and Triamterene, respectively), and Spiriva and Triamterene (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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