Spravato and Prilosec drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Spravato (esketamine hydrochloride) and Prilosec (omeprazole). Common drug interactions include weight decreased among females and dissociation among males.

The phase IV clinical study analyzes what interactions people have when they take Spravato and Prilosec. It is created by eHealthMe based on reports of 11 people who take the same drugs from the FDA, and is updated regularly.

What is Spravato?

Spravato has active ingredients of esketamine hydrochloride. eHealthMe is studying from 7,920 Spravato users. Check the latest studies of Spravato.

What is Prilosec?

Prilosec has active ingredients of omeprazole. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 175,285 Prilosec users. Check the latest studies of Prilosec.

On Jul, 30, 2026

11 people who take Spravato and Prilosec together, and have interactions are studied.

Spravato and Prilosec drug interactions.

What are the common drug interactions of Spravato and Prilosec, by gender? *:

female:

Weight decreased
Akathisia (a movement disorder characterized by a feeling of inner restlessness)
Drug ineffective
Dysphagia (a condition in which swallowing is difficult or painful)
Feeding disorder (when children refuse to eat certain food groups)
Hallucinations, mixed (sensations that appear real but are created by your mind -mixed)
Hunger
Hypomania (a mild form of mania, marked by elation and hyperactivity)
Impaired work ability
Malnutrition (a condition that results from eating a diet in which certain nutrients are lacking)

male:

Dissociation
Gait disturbance
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Speech disorder
Nausea (feeling of having an urge to vomit)
Sedation
Vomiting

What are the common drug interactions of Spravato and Prilosec, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Dissociation
Speech disorder
Gait disturbance
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Suicidal ideation
Weight decreased
Akathisia (a movement disorder characterized by a feeling of inner restlessness)
Drug ineffective
Dysphagia (a condition in which swallowing is difficult or painful)
Feeding disorder (when children refuse to eat certain food groups)

50-59:

Dissociation
Sedation
Nausea (feeling of having an urge to vomit)
Vomiting
Adverse event
Anxiety

60+:

Depressed mood
Fatigue (feeling of tiredness)
Insomnia (sleeplessness)
Malaise (a feeling of general discomfort or uneasiness)
Migraine (headache)

What are the existing conditions these people have? *

Depression: 8 people, 72.73%
Stress And Anxiety: 6 people, 54.55%
Major Depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings): 3 people, 27.27%
Tremor (trembling or shaking movements in one or more parts of your body): 2 people, 18.18%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 2 people, 18.18%
Insomnia (sleeplessness): 2 people, 18.18%
Affective Disorder (mental disorder): 2 people, 18.18%
Nausea (feeling of having an urge to vomit): 1 person, 9.09%
Nausea And Vomiting: 1 person, 9.09%
Restless Leg Syndrome (a powerful urge to move your legs): 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

Do you take Spravato and Prilosec?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously