Spravato and Vistaril drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Spravato (esketamine hydrochloride) and Vistaril (hydroxyzine hydrochloride). Common drug interactions include dissociation among females and disorientation among males.

The phase IV clinical study analyzes what interactions people have when they take Spravato and Vistaril. It is created by eHealthMe based on reports of 19 people who take the same drugs from the FDA, and is updated regularly.

What is Spravato?

Spravato has active ingredients of esketamine hydrochloride. eHealthMe is studying from 7,920 Spravato users. Check the latest studies of Spravato.

What is Vistaril?

Vistaril has active ingredients of hydroxyzine hydrochloride. It is often used in stress and anxiety. eHealthMe is studying from 9,565 Vistaril users. Check the latest studies of Vistaril.

On Jul, 13, 2026

19 people who take Spravato and Vistaril together, and have interactions are studied.

Spravato and Vistaril drug interactions.

What are the common drug interactions of Spravato and Vistaril, by gender? *:

female:

Dissociation
Suicidal ideation
Sedation
Hospitalisation
Therapeutic response decreased (less preventive response)
Adverse event
Hypertension (high blood pressure)
Drug ineffective
Major depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)

male:

Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Dizziness
Dissociation
Memory impairment
Nausea (feeling of having an urge to vomit)
Vomiting
Fall
Gait disturbance
Loss of consciousness
Sedation

What are the common drug interactions of Spravato and Vistaril, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Disturbance in attention
Dizziness
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Hallucination (an experience involving the perception of something not present)
Lacrimation increased
Loss of consciousness
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Sedation
Somnolence (a state of near-sleep, a strong desire for sleep)

30-39:

Hospitalisation
Suicidal ideation
Dissociation
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Syncope (loss of consciousness with an inability to maintain postural tone)

40-49:

Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Dizziness
Fall
Gait disturbance
Loss of consciousness
Ligament rupture (tear in ligament)
Sedation
Drug ineffective
Presyncope
Bipolar ii disorder (characterized by at least one episode of hypomania and at least one episode of major depression)

50-59:

Dissociation
Sedation
Adverse event
Hypertension (high blood pressure)
Nausea (feeling of having an urge to vomit)
Vomiting
Drug ineffective

60+:

Dissociation
Major depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings)
Suicidal ideation

What are the existing conditions these people have? *

Depression: 17 people, 89.47%
Major Depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings): 7 people, 36.84%
Sleep Disorder: 3 people, 15.79%
Attention Deficit Hyperactivity Disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness): 3 people, 15.79%
Generalized Anxiety Disorder (excessive, uncontrollable, unexplained and often irrational worry): 3 people, 15.79%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 10.53%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 2 people, 10.53%
Suicidal Ideation: 2 people, 10.53%
Drowsiness: 2 people, 10.53%
Wheezing (a high-pitched whistling sound made while you breath): 1 person, 5.26%

* Approximation only. Some reports may have incomplete information.

Do you take Spravato and Vistaril?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously