Sprintec and Ativan drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Sprintec (ethinyl estradiol; norgestimate) and Ativan (lorazepam). Common drug interactions include osteonecrosis of jaw among females and angina pectoris among males.

The phase IV clinical study analyzes what interactions people have when they take Sprintec and Ativan. It is created by eHealthMe based on reports of 36 people who take the same drugs from the FDA, and is updated regularly.

What is Sprintec?

Sprintec has active ingredients of ethinyl estradiol; norgestimate. It is often used in birth control. eHealthMe is studying from 4,397 Sprintec users. Check the latest studies of Sprintec.

What is Ativan?

Ativan has active ingredients of lorazepam. It is often used in stress and anxiety. eHealthMe is studying from 78,506 Ativan users. Check the latest studies of Ativan.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

36 people who take Sprintec and Ativan together, and have interactions are studied.

What are the common drug interactions of Sprintec and Ativan, by gender? *:

female:

Osteonecrosis of jaw (death of bone of jaw)
Pain
Pain of skin
Pancreatitis (inflammation of pancreas)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Post procedural haemorrhage (post procedural bleeding)
Psychotic disorder
Pulmonary embolism (blockage of the main artery of the lung)
Rebound effect (take-back effect)
Headache (pain in head)

male:

Angina pectoris (chest pain due to ischemia of the heart muscle)
Back pain
Hyperprolactinaemia (abnormally high levels of prolactin in the blood)
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
Limb injury
Osteopenia (a condition where bone mineral density is lower than normal)
Osteoporosis (bones weak and more likely to break)
Post-traumatic stress disorder
Rib fracture
Type 2 diabetes mellitus

What are the common drug interactions of Sprintec and Ativan, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Pain
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Urinary incontinence (inability to control the flow of urine and involuntary urination)
Vertigo
Blood pressure increased
Delusion (a false belief or opinion)
Encephalitis (inflammation of the brain)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Headache (pain in head)
Muscle spasms (muscle contraction)

20-29:

Ankylosing spondylitis (type of arthritis affecting the spine)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Blindness
Cerebral haemorrhage (bleeding within the brain)
Cerebral thrombosis (blood clot in brain)
Deafness
Headache (pain in head)
Subarachnoid haemorrhage (blood leaks into the space between two membranes that surround the brain)
Blood creatinine increased
Febrile neutropenia (fever with reduced white blood cells)

30-39:

Headache (pain in head)
Migraine (headache)
Oral herpes (viral infection of mouth)
Back pain
Eye discharge
Ocular hyperaemia (an abnormally large amount of blood in eye)
Oropharyngeal pain
Snoring
Confusional state
Suicide attempt

40-49:

Balance disorder
Enteritis (inflammation of the small intestine)
Gastrointestinal disorder (functional problems of gastrointestinal tract)
General physical health deterioration (weak health status)
Osteonecrosis of jaw (death of bone of jaw)
Pancreatitis (inflammation of pancreas)
Ulcer

50-59:

n/a

60+:

Angina pectoris (chest pain due to ischemia of the heart muscle)
Back pain
Hyperprolactinaemia (abnormally high levels of prolactin in the blood)
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
Limb injury
Osteopenia (a condition where bone mineral density is lower than normal)
Osteoporosis (bones weak and more likely to break)
Post-traumatic stress disorder
Rib fracture
Type 2 diabetes mellitus

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 16 people, 44.44%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 11 people, 30.56%
Nausea (feeling of having an urge to vomit): 5 people, 13.89%
Hypersensitivity: 4 people, 11.11%
Insomnia (sleeplessness): 3 people, 8.33%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 3 people, 8.33%
Asthma: 3 people, 8.33%
Depression: 3 people, 8.33%
Sleep Disorder: 3 people, 8.33%
Abdominal Pain: 3 people, 8.33%

* Approximation only. Some reports may have incomplete information.

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