Sprintec and Methylprednisolone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Sprintec (ethinyl estradiol; norgestimate) and Methylprednisolone (methylprednisolone). Common drug interactions include mental status changes among females.

The phase IV clinical study analyzes what interactions people have when they take Sprintec and Methylprednisolone. It is created by eHealthMe based on reports of 13 people who take the same drugs from the FDA, and is updated regularly.

What is Sprintec?

Sprintec has active ingredients of ethinyl estradiol; norgestimate. It is often used in birth control. eHealthMe is studying from 4,397 Sprintec users. Check the latest studies of Sprintec.

What is Methylprednisolone?

Methylprednisolone has active ingredients of methylprednisolone. It is often used in inflammation. eHealthMe is studying from 59,645 Methylprednisolone users. Check the latest studies of Methylprednisolone.

On Jul, 16, 2026

13 people who take Sprintec and Methylprednisolone together, and have interactions are studied.

Sprintec and Methylprednisolone drug interactions.

What are the common drug interactions of Sprintec and Methylprednisolone, by gender? *:

female:

Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Maculopathy (a condition or disease of the macula, the small spot in the retina where vision is keenest)
Nerve injury
Peroneal nerve palsy
Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints)
Ulcer
Urethral obstruction (blockage of the urethra causing difficulty with urination)
Sepsis (a severe blood infection that can lead to organ failure and death)
Hypertension (high blood pressure)
Cough

male:

n/a

What are the common drug interactions of Sprintec and Methylprednisolone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Maculopathy (a condition or disease of the macula, the small spot in the retina where vision is keenest)
Intervertebral disc protrusion (spinal disc protrusion)
Nausea (feeling of having an urge to vomit)
Nerve injury
Peroneal nerve palsy

30-39:

n/a

40-49:

Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Sepsis (a severe blood infection that can lead to organ failure and death)

50-59:

n/a

60+:

n/a

What are the existing conditions these people have? *

Stress And Anxiety: 6 people, 46.15%
Depression: 6 people, 46.15%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 4 people, 30.77%
Hypersensitivity: 4 people, 30.77%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 4 people, 30.77%
Cough: 4 people, 30.77%
Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 4 people, 30.77%
High Blood Pressure: 4 people, 30.77%
Asthma: 4 people, 30.77%
Sinusitis (inflammation of sinus): 3 people, 23.08%

* Approximation only. Some reports may have incomplete information.

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