Sprintec and Naprosyn drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Sprintec (ethinyl estradiol; norgestimate) and Naprosyn (naproxen). Common drug interactions include abdominal distension among females.

The phase IV clinical study analyzes what interactions people have when they take Sprintec and Naprosyn. It is created by eHealthMe based on reports of 12 people who take the same drugs from the FDA, and is updated regularly.

What is Sprintec?

Sprintec has active ingredients of ethinyl estradiol; norgestimate. It is often used in birth control. eHealthMe is studying from 4,397 Sprintec users. Check the latest studies of Sprintec.

What is Naprosyn?

Naprosyn has active ingredients of naproxen. It is often used in pain. eHealthMe is studying from 16,738 Naprosyn users. Check the latest studies of Naprosyn.

On Jul, 25, 2026

12 people who take Sprintec and Naprosyn together, and have interactions are studied.

Sprintec and Naprosyn drug interactions.

What are the common drug interactions of Sprintec and Naprosyn, by gender? *:

female:

Abdominal distension
Abdominal pain
Autoimmune disorder (a condition in which the immune system attacks the body's normal substances and tissue)
Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)
Pulmonary embolism (blockage of the main artery of the lung)
Thrombophlebitis superficial (swelling (inflammation) of a superficial vein caused by a blood clot)
Vaginal haemorrhage (vaginal bleeding)
Affective disorder (mental disorder)
Arthralgia (joint pain)
Arthropathy

male:

n/a

What are the common drug interactions of Sprintec and Naprosyn, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Vaginal haemorrhage (vaginal bleeding)

20-29:

Arthralgia (joint pain)
Dyspepsia (indigestion)
Dysphagia (a condition in which swallowing is difficult or painful)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Sleep-related eating disorder (abnormal eating patterns during the night)
Throat tightness

30-39:

Pulmonary embolism (blockage of the main artery of the lung)
Thrombophlebitis superficial (swelling (inflammation) of a superficial vein caused by a blood clot)
Emotional distress
Injury

40-49:

Abdominal distension
Abdominal pain
Haemangioma of skin (noncancerous, abnormally dense collections of dilated small blood vessels that may occur in the skin or internal organs)
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Device dislocation
Dysmenorrhoea (painful menstruation)
Fatigue (feeling of tiredness)
Lymphocyte count decreased
Menorrhagia (an abnormally heavy bleeding and prolonged menstrual period at regular intervals)
Migraine (headache)

50-59:

n/a

60+:

n/a

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 4 people, 33.33%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 4 people, 33.33%
Depression: 4 people, 33.33%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 4 people, 33.33%
Migraine Without Aura (headache without neurological problems): 3 people, 25.00%
Hypertonic Bladder (bladder-storage function that causes a sudden urge to urinate): 3 people, 25.00%
Acne (skin problems that cause pimples): 2 people, 16.67%
Stress And Anxiety: 1 person, 8.33%
Restless Leg Syndrome (a powerful urge to move your legs): 1 person, 8.33%
Joint Pain: 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

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