Sprintec and Palynziq drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Sprintec (ethinyl estradiol; norgestimate) and Palynziq (pegvaliase-pqpz). Common drug interactions include arthralgia among females.

The phase IV clinical study analyzes what interactions people have when they take Sprintec and Palynziq. It is created by eHealthMe based on reports of 13 people who take the same drugs from the FDA, and is updated regularly.

What is Sprintec?

Sprintec has active ingredients of ethinyl estradiol; norgestimate. It is often used in birth control. eHealthMe is studying from 4,397 Sprintec users. Check the latest studies of Sprintec.

What is Palynziq?

Palynziq has active ingredients of pegvaliase-pqpz. eHealthMe is studying from 6,071 Palynziq users. Check the latest studies of Palynziq.



On Jul, 25, 2026

13 people who take Sprintec and Palynziq together, and have interactions are studied.

Sprintec and Palynziq drug interactions.

What are the common drug interactions of Sprintec and Palynziq, by gender? *:

female:

  1. Arthralgia (joint pain)
  2. Hypersensitivity
  3. Tremor (trembling or shaking movements in one or more parts of your body)
  4. Anxiety
  5. Heart rate increased
  6. Injection site erythema (redness at injection site)
  7. Injection site pain
  8. Injection site rash
  9. Decreased appetite
  10. Injection site swelling

male:

n/a

What are the common drug interactions of Sprintec and Palynziq, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

  1. Hypersensitivity
  2. Injection site swelling

20-29:

  1. Dyspnoea (difficult or laboured respiration)
  2. Tremor (trembling or shaking movements in one or more parts of your body)

30-39:

  1. Arthralgia (joint pain)
  2. Alopecia (absence of hair from areas of the body)
  3. Injection site rash
  4. Injection site swelling
  5. Aphonia (inability to produce voice)
  6. Chills (felling of cold)
  7. Muscle strain (an injury to a muscle in which the muscle fibres tear)
  8. Nasopharyngitis (inflammation of the nasopharynx)
  9. Anxiety
  10. Heart rate increased

40-49:

n/a

50-59:

n/a

60+:

n/a

* Approximation only. Some reports may have incomplete information.

Do you take Sprintec and Palynziq?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Sprintec and Palynziq:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Sprintec:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Palynziq:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Sprintec and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Palynziq and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on ethinyl estradiol; norgestimate and pegvaliase-pqpz (the active ingredients of Sprintec and Palynziq, respectively), and Sprintec and Palynziq (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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