Stivarga and Compazine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Stivarga (regorafenib) and Compazine (prochlorperazine maleate). Common drug interactions include abdominal pain among females and asthenia among males.

The phase IV clinical study analyzes what interactions people have when they take Stivarga and Compazine. It is created by eHealthMe based on reports of 24 people who take the same drugs from the FDA, and is updated regularly.

What is Stivarga?

Stivarga has active ingredients of regorafenib. eHealthMe is studying from 9,539 Stivarga users. Check the latest studies of Stivarga.

What is Compazine?

Compazine has active ingredients of prochlorperazine maleate. It is often used in nausea and vomiting. eHealthMe is studying from 13,646 Compazine users. Check the latest studies of Compazine.

On Aug, 08, 2026

24 people who take Stivarga and Compazine together, and have interactions are studied.

Stivarga and Compazine drug interactions.

What are the common drug interactions of Stivarga and Compazine, by gender? *:

female:

Abdominal pain
Abdominal pain lower
Activities of daily living impaired
Arthralgia (joint pain)
Bedridden
Constipation
Death
Dehydration (dryness resulting from the removal of water)
Drug intolerance (drug sensitivity)
Dyspnoea exertional (breathlessness or shortness of breath)

male:

Asthenia (weakness)
Fatigue (feeling of tiredness)
Colorectal cancer metastatic (cancer of colon and rectal spreads to other parts)
Constipation
Decreased appetite
Dysphonia (speech disorder attributable to a disorder of phonation)
Hypoaesthesia (reduced sense of touch or sensation)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Libido decreased (loss of interest in sex)
Metastases to bone (cancer spreads to bone)

What are the common drug interactions of Stivarga and Compazine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Back pain
Oropharyngeal pain
Pain
Pain in extremity
Palmar-plantar erythrodysaesthesia syndrome (hand-foot syndrome)
Stomatitis (inflammation of mucous membrane of mouth)

40-49:

Blood glucose increased
Blood pressure increased
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Death
Facial paralysis (loss of function of face muscle)
Fatigue (feeling of tiredness)
Hypersensitivity
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Metastases to liver (cancer spreads to liver)
Mobility decreased (ability to move is reduced)

50-59:

Disease progression
Disseminated intravascular coagulation (systemic activation of blood coagulation)
Drug ineffective
Dyspnoea exertional (breathlessness or shortness of breath)
Encephalopathy (functioning of the brain is affected by some agent or condition)
Gastritis (inflammation of stomach)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Generalised oedema (swelling all over the body)
Haematemesis (vomiting of blood)
Haemoglobin decreased

60+:

Asthenia (weakness)
Hospitalisation
Decreased appetite
Drug intolerance (drug sensitivity)
Dyspnoea exertional (breathlessness or shortness of breath)
Dysuria (painful or difficult urination)
Failure to thrive (inadequate weight gain and physical growth in children)
Fatigue (feeling of tiredness)
Gait disturbance
Hyperbilirubinaemia (excess of bilirubin in the blood)

What are the existing conditions these people have? *

Colon Cancer: 12 people, 50.00%
Nausea (feeling of having an urge to vomit): 4 people, 16.67%
Colon Cancer Metastatic (cancer of colon spreads to other part of body): 4 people, 16.67%
Rectal Cancer (cancer of rectum): 3 people, 12.50%
Diarrhea: 2 people, 8.33%

* Approximation only. Some reports may have incomplete information.

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