Stivarga and Entecavir drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Stivarga (regorafenib) and Entecavir (entecavir). Common drug interactions include hypertension among females and hepatocellular carcinoma among males.

The phase IV clinical study analyzes what interactions people have when they take Stivarga and Entecavir. It is created by eHealthMe based on reports of 22 people who take the same drugs from the FDA, and is updated regularly.

What is Stivarga?

Stivarga has active ingredients of regorafenib. eHealthMe is studying from 9,539 Stivarga users. Check the latest studies of Stivarga.

What is Entecavir?

Entecavir has active ingredients of entecavir. It is often used in hepatitis b. eHealthMe is studying from 7,354 Entecavir users. Check the latest studies of Entecavir.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 19, 2026

22 people who take Stivarga and Entecavir together, and have interactions are studied.

Stivarga and Entecavir drug interactions.

What are the common drug interactions of Stivarga and Entecavir, by gender? *:

female:

Hypertension (high blood pressure)
Decreased appetite
Diarrhoea
Drug resistance (reduction in effectiveness of a drug)
Large intestine perforation (hole in large intestine)
Palmar-plantar erythrodysaesthesia syndrome (hand-foot syndrome)
Proteinuria (presence of protein in the urine)
Pyrexia (fever)
Back pain
Blood pressure increased

male:

Hepatocellular carcinoma (liver cancer)
Metastases to lung (cancer spreads to lung)
Splenic vein thrombosis (blood clot in splenic vein)
Tumour embolism (blockage due to tumour in circulation)
Malaise (a feeling of general discomfort or uneasiness)
Pancreatitis acute (sudden inflammation of pancreas)
Abdominal mass (localized enlargement or swelling in the human abdomen)
Alanine aminotransferase increased
Ammonia increased
Asterixis (flapping tremor, or liver flap)

What are the common drug interactions of Stivarga and Entecavir, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Hepatocellular carcinoma (liver cancer)
Metastases to lung (cancer spreads to lung)
Abdominal mass (localized enlargement or swelling in the human abdomen)
Bronchiolitis (inflammation of the membranes lining the bronchioles in lungs)
Cholecystitis (infection of gallbladder)
Gallbladder disorder
Pulmonary fibrosis (formation or development of excess fibrous connective tissue (fibrosis) in the lungs)
Pulmonary mass
Renal cyst (kidney cyst)
Abdominal pain upper

50-59:

Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Hepatocellular carcinoma (liver cancer)
Blood pressure increased
Malaise (a feeling of general discomfort or uneasiness)
Diarrhoea
Drug resistance (reduction in effectiveness of a drug)
Hypertension (high blood pressure)
Large intestine perforation (hole in large intestine)
Metastases to lung (cancer spreads to lung)
Palmar-plantar erythrodysaesthesia syndrome (hand-foot syndrome)

60+:

Hepatocellular carcinoma (liver cancer)
Metastases to lung (cancer spreads to lung)
Tumour embolism (blockage due to tumour in circulation)
Alanine aminotransferase increased
Ammonia increased
Asterixis (flapping tremor, or liver flap)
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Decreased appetite
Drug intolerance (drug sensitivity)
Hepatic encephalopathy (spectrum of neuropsychiatric abnormalities in patients with liver failure)

What are the existing conditions these people have? *

Hepatocellular Carcinoma (liver cancer): 16 people, 72.73%
Metastases To Lung (cancer spreads to lung): 2 people, 9.09%
Metastases To Bone (cancer spreads to bone): 2 people, 9.09%

* Approximation only. Some reports may have incomplete information.

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