Stivarga and Hydramine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Stivarga (regorafenib) and Hydramine (diphenhydramine hydrochloride). Common drug interactions include dyspepsia among females and fatigue among males.

The phase IV clinical study analyzes what interactions people have when they take Stivarga and Hydramine. It is created by eHealthMe based on reports of 36 people who take the same drugs from the FDA, and is updated regularly.

What is Stivarga?

Stivarga has active ingredients of regorafenib. eHealthMe is studying from 9,539 Stivarga users. Check the latest studies of Stivarga.

What is Hydramine?

Hydramine has active ingredients of diphenhydramine hydrochloride. It is often used in insomnia. eHealthMe is studying from 114,900 Hydramine users. Check the latest studies of Hydramine.

On Jul, 13, 2026

36 people who take Stivarga and Hydramine together, and have interactions are studied.

Stivarga and Hydramine drug interactions.

What are the common drug interactions of Stivarga and Hydramine, by gender? *:

female:

Dyspepsia (indigestion)
Faeces hard
Gastritis (inflammation of stomach)
Hot flush (sudden feelings of heat)
Hyperhidrosis (abnormally increased sweating)
Hypertension (high blood pressure)
Incision site pain
Incision site pruritus (itching around the incision site)
Lower gastrointestinal haemorrhage (bleeding in the large intestine, rectum, or anus is called lower gi bleeding)
Memory impairment

male:

Fatigue (feeling of tiredness)
Pain in extremity
Weight decreased
Arrhythmia (irregular heartbeat)
Chest discomfort
Surgery
Urinary incontinence (inability to control the flow of urine and involuntary urination)
Dry skin
Musculoskeletal disorder (disease of the body's muscles, joints, tendons, ligaments and nerves)
Skin exfoliation (removal of the oldest dead skin cells)

What are the common drug interactions of Stivarga and Hydramine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Abdominal pain upper
Fatigue (feeling of tiredness)
Pain in extremity
Rash
Skin exfoliation (removal of the oldest dead skin cells)
Dry skin
Musculoskeletal disorder (disease of the body's muscles, joints, tendons, ligaments and nerves)
Palmar-plantar erythrodysaesthesia syndrome (hand-foot syndrome)
Decreased appetite
Eating disorder

50-59:

Colorectal cancer metastatic (cancer of colon and rectal spreads to other parts)
Neuropathy peripheral (surface nerve damage)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Ammonia increased
Blood bilirubin increased
Colon cancer metastatic (cancer of colon spreads to other part of body)
Asthenia (weakness)
Decreased appetite
Rash erythematous (redness of the skin)
Sluggishness (lacking alertness)

60+:

Blood pressure increased
Fatigue (feeling of tiredness)
Surgery
Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Erythema (redness of the skin)
Faeces hard
Haemorrhoids (a swollen vein or group of veins in the region of the anus)
Headache (pain in head)
Dysphonia (speech disorder attributable to a disorder of phonation)
Pulmonary mass

What are the existing conditions these people have? *

Colon Cancer: 11 people, 30.56%
Colorectal Cancer Metastatic (cancer of colon and rectal spreads to other parts): 10 people, 27.78%
Rectal Cancer (cancer of rectum): 8 people, 22.22%
Inflammation: 3 people, 8.33%
Hypersensitivity: 3 people, 8.33%
Gastrointestinal Stromal Tumor: 3 people, 8.33%
Stress And Anxiety: 2 people, 5.56%
Pain: 2 people, 5.56%
Nausea (feeling of having an urge to vomit): 2 people, 5.56%
Metastases To Retroperitoneum (cancer spreads to retroperitonium): 2 people, 5.56%

* Approximation only. Some reports may have incomplete information.

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