Strattera and Methylphenidate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Strattera (atomoxetine hydrochloride) and Methylphenidate (methylphenidate). Common drug interactions include hypoacusis among females and anxiety among males.

The phase IV clinical study analyzes what interactions people have when they take Strattera and Methylphenidate. It is created by eHealthMe based on reports of 72 people who take the same drugs from the FDA, and is updated regularly.

What is Strattera?

Strattera has active ingredients of atomoxetine hydrochloride. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 29,324 Strattera users. Check the latest studies of Strattera.

What is Methylphenidate?

Methylphenidate has active ingredients of methylphenidate. eHealthMe is studying from 8,217 Methylphenidate users. Check the latest studies of Methylphenidate.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

72 people who take Strattera and Methylphenidate together, and have interactions are studied.

Strattera and Methylphenidate drug interactions.

What are the common drug interactions of Strattera and Methylphenidate, by gender? *:

female:

Hypoacusis (loss of hearing)
Hypotension (abnormally low blood pressure)
Influenza
Inner ear disorder
Intervertebral disc degeneration (spinal disc degeneration)
Lymphatic fistula (a leakage of lymphatic fluid from lymphatic vessel)
Middle ear effusion (fluid in middle ear)
Multiple allergies (allergy to multiple agents)
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Nasopharyngitis (inflammation of the nasopharynx)

male:

Anxiety
Burkitt's lymphoma stage iv (blood cancer stage iv)
Suicidal ideation
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Encephalitis autoimmune (autoimmune origin disturbances of consciousness and pyramidal signs, inflammation of the brain)
Facial paresis (weakness in facial muscle movement)
Muscular weakness (muscle weakness)
Psychotic disorder
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Ankle fracture

What are the common drug interactions of Strattera and Methylphenidate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Burkitt's lymphoma stage iv (blood cancer stage iv)
Epstein-barr virus infection
Post transplant lymphoproliferative disorder
Abdominal discomfort
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Bacteraemia (presence of bacteria in the blood)
Respiratory distress (difficulty in breathing)

10-19:

Hospitalisation
Gout (uric acid crystals building up in the body)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Drug dependence
Limb traumatic amputation (loss of leg due to injury)
Overdose
Adverse drug reaction
Anxiety
Disturbance in attention
Drug ineffective

20-29:

Fibromyalgia (a long-term condition which causes pain all over the body)
Headache (pain in head)
Hot flush (sudden feelings of heat)
Hypersensitivity
Intervertebral disc degeneration (spinal disc degeneration)
Intervertebral disc protrusion (spinal disc protrusion)
Irritability
Major depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings)
Migraine (headache)
Pain

30-39:

Drug ineffective
Somnambulism (sleep walking)
Adrenal disorder
Adverse reaction
Chills (felling of cold)
Confusional state
Cough
Feeling drunk
Headache (pain in head)
Hip fracture

40-49:

Alopecia (absence of hair from areas of the body)
Fatigue (feeling of tiredness)
Intervertebral disc degeneration (spinal disc degeneration)
Neuralgia (pain in one or more nerves)
Rib fracture
Victim of abuse
Chronic kidney disease
Autoimmune hepatitis
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hospitalisation

50-59:

Psychotic disorder
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Drug ineffective
Ear infection fungal
Fatigue (feeling of tiredness)
Somnolence (a state of near-sleep, a strong desire for sleep)

60+:

Cystitis (inflammation of the wall of the bladder)
Dizziness
Lymphatic fistula (a leakage of lymphatic fluid from lymphatic vessel)
Malaise (a feeling of general discomfort or uneasiness)
Middle ear effusion (fluid in middle ear)
Multiple allergies (allergy to multiple agents)
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Nasopharyngitis (inflammation of the nasopharynx)
Productive cough
Pulmonary embolism (blockage of the main artery of the lung)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 32 people, 44.44%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 23 people, 31.94%
High Blood Pressure: 7 people, 9.72%
Pain: 6 people, 8.33%
Drowsiness: 6 people, 8.33%

* Approximation only. Some reports may have incomplete information.

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