Sublimaze and Hydramine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Sublimaze (fentanyl citrate) and Hydramine (diphenhydramine hydrochloride). Common drug interactions include haemorrhagic stroke among females and duodenal ulcer haemorrhage among males.

The phase IV clinical study analyzes what interactions people have when they take Sublimaze and Hydramine. It is created by eHealthMe based on reports of 25 people who take the same drugs from the FDA, and is updated regularly.

What is Sublimaze?

Sublimaze has active ingredients of fentanyl citrate. eHealthMe is studying from 560 Sublimaze users. Check the latest studies of Sublimaze.

What is Hydramine?

Hydramine has active ingredients of diphenhydramine hydrochloride. It is often used in insomnia. eHealthMe is studying from 114,900 Hydramine users. Check the latest studies of Hydramine.

On Jul, 28, 2026

25 people who take Sublimaze and Hydramine together, and have interactions are studied.

Sublimaze and Hydramine drug interactions.

What are the common drug interactions of Sublimaze and Hydramine, by gender? *:

female:

Haemorrhagic stroke (stroke caused by the rupture of a blood vessel in the brain)
Haemothorax (collection of blood in the pleural space (the space between the lungs and the walls of the chest))
Hypokalaemia (low potassium)
Hypoventilation (too shallow or too slow breathing, which does not meet the needs of the body)
Ileus (a painful obstruction of the ileum or other part of the intestine)
Libido decreased (loss of interest in sex)
Lobar pneumonia (a form of pneumonia that affects a large and continuous area of the lobe of a lung)
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Muscle rigidity (muscle stiffness)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)

male:

Duodenal ulcer haemorrhage (bleeding duodenal ulcer)
Large intestine perforation (hole in large intestine)
Fluid overload (too much fluid in the blood)
Fluid retention (an abnormal accumulation of fluid in the blood)
Hypoxia (low oxygen in tissues)
Leukopenia (less number of white blood cells in blood)
Liver disorder (liver diseases)
Lung infection
Neutropenia (an abnormally low number of neutrophils)
Oesophageal candidiasis (fungal infection of oesophagus)

What are the common drug interactions of Sublimaze and Hydramine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Wound secretion

20-29:

n/a

30-39:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Compulsive sexual behaviour (unable to manage his/her sexual behaviour)
Compulsive shopping
Disability
Eating disorder
Emotional distress
Epistaxis (bleed from the nose)
Impulse-control disorder
Injury

40-49:

Muscle rigidity (muscle stiffness)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Pain
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Parkinson's disease
Personality change
Renal failure (kidney dysfunction)
Social avoidant behaviour (avoiding social connection a personality disorder)
Somnolence (a state of near-sleep, a strong desire for sleep)
Speech disorder

50-59:

Stomatitis (inflammation of mucous membrane of mouth)
Acute respiratory failure
Cardiac failure congestive
Cytomegalovirus viraemia (cytomegalo virus in blood stream)
Fluid overload (too much fluid in the blood)
Fluid retention (an abnormal accumulation of fluid in the blood)
Hypoxia (low oxygen in tissues)
Leukopenia (less number of white blood cells in blood)
Neutropenia (an abnormally low number of neutrophils)
Oesophageal candidiasis (fungal infection of oesophagus)

60+:

Sepsis (a severe blood infection that can lead to organ failure and death)
Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)
Malnutrition (a condition that results from eating a diet in which certain nutrients are lacking)
Neutropenia (an abnormally low number of neutrophils)
Oral candidiasis (fungal infection of mouth)
Platelet count decreased
Pleural effusion (water on the lungs)
Pyrexia (fever)
Rales (an abnormal respiratory sound characterized by fine crackles)
Anaemia (lack of blood)

What are the existing conditions these people have? *

Acute Myeloid Leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts): 4 people, 16.00%
High Blood Pressure: 4 people, 16.00%
Weight Increased: 3 people, 12.00%
Itching: 3 people, 12.00%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 3 people, 12.00%
Constipation: 3 people, 12.00%
Cough: 3 people, 12.00%
Dyspnea (difficult or laboured breathing): 3 people, 12.00%
Folate Deficiency (lack of folic acid): 3 people, 12.00%
Fungal Infection: 3 people, 12.00%

* Approximation only. Some reports may have incomplete information.

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