Sublimaze and Maxipime drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Sublimaze (fentanyl citrate) and Maxipime (cefepime hydrochloride). Common drug interactions include platelet count decreased among females and pyrexia among males.

The phase IV clinical study analyzes what interactions people have when they take Sublimaze and Maxipime. It is created by eHealthMe based on reports of 56 people who take the same drugs from the FDA, and is updated regularly.

What is Sublimaze?

Sublimaze has active ingredients of fentanyl citrate. eHealthMe is studying from 560 Sublimaze users. Check the latest studies of Sublimaze.

What is Maxipime?

Maxipime has active ingredients of cefepime hydrochloride. eHealthMe is studying from 4,279 Maxipime users. Check the latest studies of Maxipime.

On Jul, 17, 2026

56 people who take Sublimaze and Maxipime together, and have interactions are studied.

Sublimaze and Maxipime drug interactions.

What are the common drug interactions of Sublimaze and Maxipime, by gender? *:

female:

Platelet count decreased
Pain in extremity
Sepsis (a severe blood infection that can lead to organ failure and death)
Rash maculo-papular (red area on the skin that is covered with small confluent bumps)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Hypoxia (low oxygen in tissues)
Peripheral swelling
Respiratory failure (inadequate gas exchange by the respiratory system)
Systemic inflammatory response syndrome (an inflammatory state affecting the whole body, frequently a response of the immune system to infection)
Abdominal pain

male:

Pyrexia (fever)
Diarrhoea
Infective pulmonary exacerbation of cystic fibrosis (severe infective lung disease with production of abnormally thick mucus)
Musculoskeletal chest pain (pain in chest muscle or nerve or bones)
Night sweats (sweating in night)
Productive cough
Pruritus (severe itching of the skin)
Pseudomonas test positive
Secretion discharge
Sputum discoloured

What are the common drug interactions of Sublimaze and Maxipime, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Hypertension (high blood pressure)
Infection
Cardiac failure
Overdose
Pulmonary hypertension (increase in blood pressure in the lung artery)
Respiratory failure (inadequate gas exchange by the respiratory system)

10-19:

Acute lymphocytic leukaemia recurrent (cancer in which the bone marrow makes too many lymphocytes-recurrent)
Blood creatinine increased
Blood lactic acid increased
Blood urea increased
Bone marrow failure
Bradycardia (abnormally slow heart action)
Cytokine release syndrome (immediate complication occurring with the use of anti-t cell antibody infusions)
Cytokine storm (over-protective immune response that can actually be fatal)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Haematuria (presence of blood in urine)

20-29:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Chronic kidney disease
Death
Decreased activity
Emotional distress
Fear
Impaired work ability
Pain
Quality of life decreased

30-39:

Asthenia (weakness)
Chest discomfort
Chest pain
Cough
Decreased appetite
Diarrhoea
Dyspnoea (difficult or laboured respiration)
Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)
Headache (pain in head)
Infective pulmonary exacerbation of cystic fibrosis (severe infective lung disease with production of abnormally thick mucus)

40-49:

Cytokine release syndrome (immediate complication occurring with the use of anti-t cell antibody infusions)
Drug ineffective
Infection
Sinus tachycardia (a heart rhythm with elevated rate of impulses originating from the sinoatrial node)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
B-cell lymphoma (blood cancer affecting b cells)
B-cell lymphoma recurrent (blood cancer affecting b cells-recurrent)
Bacteraemia (presence of bacteria in the blood)
Bacterial sepsis
Disseminated intravascular coagulation (systemic activation of blood coagulation)

50-59:

Perirectal abscess
Rectal abscess (pus in rectum)
Renal failure (kidney dysfunction)
Renal tubular necrosis (death of kidney tubules)
Retroperitoneal abscess (a collection of pus between the peritoneum and the posterior abdominal wall. retroperitoneal. behind the peritoneum)
Tooth abscess (pus formation in tooth)
Urinary tract infection
Urine output decreased
Vaginal abscess
Febrile neutropenia (fever with reduced white blood cells)

60+:

Diarrhoea
Anaemia (lack of blood)
Bacteraemia (presence of bacteria in the blood)
Cytokine release syndrome (immediate complication occurring with the use of anti-t cell antibody infusions)
Device failure
Hypoglycaemia (deficiency of glucose in the bloodstream)
Hypokalaemia (low potassium)
Pneumonia
Small intestinal obstruction (blockage in small intestine)
Alanine aminotransferase increased

What are the existing conditions these people have? *

Pain: 17 people, 30.36%
Hypotension (abnormally low blood pressure): 13 people, 23.21%
Constipation: 13 people, 23.21%
Cough: 12 people, 21.43%
Stress And Anxiety: 12 people, 21.43%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 10 people, 17.86%
Nausea (feeling of having an urge to vomit): 10 people, 17.86%
Pain In Extremity: 10 people, 17.86%
Sedation: 8 people, 14.29%
Depression: 8 people, 14.29%

* Approximation only. Some reports may have incomplete information.

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