Subutex and Atarax drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Subutex (buprenorphine hydrochloride) and Atarax (hydroxyzine hydrochloride). Common drug interactions include withdrawal syndrome among females and somnolence among males.

The phase IV clinical study analyzes what interactions people have when they take Subutex and Atarax. It is created by eHealthMe based on reports of 61 people who take the same drugs from the FDA, and is updated regularly.

What is Subutex?

Subutex has active ingredients of buprenorphine hydrochloride. It is often used in opiate withdrawal. eHealthMe is studying from 8,763 Subutex users. Check the latest studies of Subutex.

What is Atarax?

Atarax has active ingredients of hydroxyzine hydrochloride. It is often used in stress and anxiety. eHealthMe is studying from 23,553 Atarax users. Check the latest studies of Atarax.

On Jul, 13, 2026

61 people who take Subutex and Atarax together, and have interactions are studied.

What are the common drug interactions of Subutex and Atarax, by gender? *:

female:

Withdrawal syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance)
Drug abuse
Substance abuse
Acute generalised exanthematous pustulosis (acute febrile drug eruption)
Adrenal insufficiency (a condition in which the adrenal glands do not produce adequate amounts of steroids)
Angioneurotic oedema (swelling that occurs just beneath the surface of the skin or mucous membranes)
Asthenia (weakness)
Blood cortisol decreased
Blood creatine phosphokinase increased
Blood thyroid stimulating hormone increased

male:

Somnolence (a state of near-sleep, a strong desire for sleep)
Agitation (state of anxiety or nervous excitement)
Drug abuse
Drug exposure during pregnancy
Suicidal ideation
Suicide attempt
Drug ineffective
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Abdominal distension
Bradycardia (abnormally slow heart action)

What are the common drug interactions of Subutex and Atarax, by age (0-1 to 60+)? *:

0-1:

Drug withdrawal syndrome neonatal (prenatal nas is caused by discontinuation of drugs taken by the pregnant mother)
Agitation (state of anxiety or nervous excitement)
Crying
Foetal exposure during pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect)
Foetal malnutrition (soft tissue wasting at birth)
Hyperhidrosis (abnormally increased sweating)
Irritability
Muscle rigidity (muscle stiffness)
Neonatal tachypnoea (a slow breathing in neonate)
Tremor (trembling or shaking movements in one or more parts of your body)

2-9:

n/a

10-19:

Balance disorder
Demyelination (loss of the myelin covering of some nerve fibres resulting in their impaired function)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Skin lesion
Substance abuse

20-29:

Coma (state of unconsciousness lasting more than six hours)
Suicide attempt
Drug toxicity
Abnormal behaviour
Dyspnoea (difficult or laboured respiration)
Overdose
Respiratory failure (inadequate gas exchange by the respiratory system)
Blood creatinine increased
Death
Dehydration (dryness resulting from the removal of water)

30-39:

Hospitalisation
Hyperreflexia (overactive or over responsive reflexes)
Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down)
Sleep disorder
Substance abuse
Suicidal ideation
Tooth abscess (pus formation in tooth)
Agitation (state of anxiety or nervous excitement)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Irritability

40-49:

Somnolence (a state of near-sleep, a strong desire for sleep)
Decubitus ulcer (a chronic ulcer of the skin caused by prolonged pressure on it)
Dysarthria (speech disorder)
Monoparesis (one limb is very weak, but not completely paralyzed)
Drug abuse
Drug ineffective
Bradycardia (abnormally slow heart action)
Miosis (constriction of the pupil of the eye, resulting from a normal response to an increase in light)
Depression
Drug diversion

50-59:

Hepatocellular carcinoma (liver cancer)
Hospitalisation
Metastases to lung (cancer spreads to lung)
Somnolence (a state of near-sleep, a strong desire for sleep)
Weight increased
Withdrawal syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance)
Acute generalised exanthematous pustulosis (acute febrile drug eruption)
Adrenal insufficiency (a condition in which the adrenal glands do not produce adequate amounts of steroids)
Asthenia (weakness)
Blood cortisol decreased

60+:

Gallbladder empyema (a collection of pus within a naturally existing anatomical cavity of gallbladder)
Septic shock (shock due to blood infection)

What are the existing conditions these people have? *

Psychotic Disorder: 7 people, 11.48%
Hepatitis C: 6 people, 9.84%
Drug Dependence: 6 people, 9.84%
Drug Withdrawal Syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation): 4 people, 6.56%

* Approximation only. Some reports may have incomplete information.

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