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Subutex and Dhc plus drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Subutex (buprenorphine hydrochloride) and Dhc plus (acetaminophen; caffeine; dihydrocodeine bitartrate). Common drug interactions include drug dependence among females and drug dependence among males.

The phase IV clinical study analyzes what interactions people have when they take Subutex and Dhc plus. It is created by eHealthMe based on reports of 12 people who take the same drugs from the FDA, and is updated regularly.

What is Subutex?

Subutex has active ingredients of buprenorphine hydrochloride. It is often used in opiate withdrawal. eHealthMe is studying from 8,763 Subutex users. Check the latest studies of Subutex.

What is Dhc plus?

Dhc plus has active ingredients of acetaminophen; caffeine; dihydrocodeine bitartrate. It is often used in pain. eHealthMe is studying from 1,390 Dhc plus users. Check the latest studies of Dhc plus.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 04, 2026

12 people who take Subutex and Dhc plus together, and have interactions are studied.

Subutex and Dhc plus drug interactions.

What are the common drug interactions of Subutex and Dhc Plus, by gender? *:

female:

  1. Drug dependence
  2. Aggression
  3. Anger
  4. Depression
  5. Disability
  6. Drug abuse
  7. Emotional distress
  8. Influenza like illness
  9. Maternal exposure during pregnancy (use of substance during pregnancy)
  10. Overdose

male:

  1. Drug dependence
  2. Emotional distress
  3. Death
  4. Dependence
  5. Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
  6. Overdose
  7. Disability
  8. Developmental delay
  9. Drug withdrawal syndrome neonatal (prenatal nas is caused by discontinuation of drugs taken by the pregnant mother)
  10. Foetal exposure during pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect)

* Approximation only. Some reports may have incomplete information.

Do you take Subutex and Dhc plus?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Subutex and Dhc plus:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Subutex:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Dhc plus:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Subutex and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Dhc plus and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on buprenorphine hydrochloride and acetaminophen; caffeine; dihydrocodeine bitartrate (the active ingredients of Subutex and Dhc plus, respectively), and Subutex and Dhc plus (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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