Subutex and Soma drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Subutex (buprenorphine hydrochloride) and Soma (carisoprodol). Common drug interactions include drug dependence among females and dental caries among males.

The phase IV clinical study analyzes what interactions people have when they take Subutex and Soma. It is created by eHealthMe based on reports of 27 people who take the same drugs from the FDA, and is updated regularly.

What is Subutex?

Subutex has active ingredients of buprenorphine hydrochloride. It is often used in opiate withdrawal. eHealthMe is studying from 8,763 Subutex users. Check the latest studies of Subutex.

What is Soma?

Soma has active ingredients of carisoprodol. It is often used in muscle spasms. eHealthMe is studying from 17,137 Soma users. Check the latest studies of Soma.

On Aug, 09, 2026

27 people who take Subutex and Soma together, and have interactions are studied.

What are the common drug interactions of Subutex and Soma, by gender? *:

female:

Drug dependence
Depression
Emotional distress
Abortion spontaneous (naturally occurring miscarriage)
Anxiety
Cardiac failure congestive
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Substance abuse
Weight decreased
Withdrawal syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance)

male:

Dental caries
Mental disorder due to a general medical condition (abnormal a mental or behavioural pattern due to medicine)
Gingival infection (gum infection)
Gingivitis (inflammation of gums)
Overdose
Tremor (trembling or shaking movements in one or more parts of your body)
Constipation
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Drug ineffective
Drug toxicity

What are the common drug interactions of Subutex and Soma, by age (0-1 to 60+)? *:

0-1:

Abdominal discomfort
Depression
Insomnia (sleeplessness)
Palpitations (feelings or sensations that your heart is pounding or racing)
Panic disorder
Weight decreased

2-9:

n/a

10-19:

n/a

20-29:

Anxiety
Arthralgia (joint pain)
Drug dependence
Insomnia (sleeplessness)
Intervertebral disc disorder (spinal disc disorder)
Kyphoscoliosis (abnormal curving of the spine)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Neck pain
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Overdose

30-39:

Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Dental caries
Drug dependence
Drug toxicity
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Mental disorder due to a general medical condition (abnormal a mental or behavioural pattern due to medicine)
Substance abuse
Suicide attempt
Accident at work
Alcohol problem

40-49:

Abortion spontaneous (naturally occurring miscarriage)
Blood cholesterol increased
Drug exposure during pregnancy
Drug withdrawal syndrome neonatal (prenatal nas is caused by discontinuation of drugs taken by the pregnant mother)
Hypertension (high blood pressure)
Injection site infection
Injection site nodule (small swelling or aggregation of cells in the body, esp. an abnormal one at injection site)
Maternal exposure during pregnancy (use of substance during pregnancy)
Therapeutic response decreased (less preventive response)
Tremor (trembling or shaking movements in one or more parts of your body)

50-59:

Constipation
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Oedema peripheral (superficial swelling)
Drug dependence
Drug ineffective
Libido decreased (loss of interest in sex)
Loss of consciousness
Nausea (feeling of having an urge to vomit)
Overdose
Tremor (trembling or shaking movements in one or more parts of your body)

60+:

n/a

What are the existing conditions these people have? *

Neck Pain: 8 people, 29.63%
Back Pain: 5 people, 18.52%
Sleep Disorder: 4 people, 14.81%
Drug Dependence: 3 people, 11.11%
Stress And Anxiety: 2 people, 7.41%
Restless Leg Syndrome (a powerful urge to move your legs): 2 people, 7.41%
Pain: 2 people, 7.41%
Fibromyalgia (a long-term condition which causes pain all over the body): 2 people, 7.41%
Bipolar Disorder (mood disorder): 2 people, 7.41%
Back Injury: 2 people, 7.41%

* Approximation only. Some reports may have incomplete information.

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