Sudafed and Asa drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Sudafed (pseudoephedrine hydrochloride) and Asa (aspirin). Common drug interactions include pregnancy among females and bone pain among males.

The phase IV clinical study analyzes what interactions people have when they take Sudafed and Asa. It is created by eHealthMe based on reports of 35 people who take the same drugs from the FDA, and is updated regularly.

What is Sudafed?

Sudafed has active ingredients of pseudoephedrine hydrochloride. It is often used in nasal congestion. eHealthMe is studying from 12,944 Sudafed users. Check the latest studies of Sudafed.

What is Asa?

Asa has active ingredients of aspirin. It is often used in blood clots. eHealthMe is studying from 32,557 Asa users. Check the latest studies of Asa.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 22, 2026

35 people who take Sudafed and Asa together, and have interactions are studied.

What are the common drug interactions of Sudafed and Asa, by gender? *:

female:

Pregnancy
Pyrexia (fever)
Sinusitis (inflammation of sinus)
Skin burning sensation
Skin exfoliation (removal of the oldest dead skin cells)
Skin tightness
Solar urticaria (an abnormal reaction to sunlight)
Swelling face
Temperature intolerance (inability to go in temperature)
Tinnitus (a ringing in the ears)

male:

Bone pain
Diarrhoea
Cough
Drug ineffective
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Flatulence (flatus expelled through the anus)
Flushing (the warm, red condition of human skin)
Grip strength decreased

What are the common drug interactions of Sudafed and Asa, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Drug hypersensitivity
Foetal death (death of foetus)
Pregnancy
Sinusitis (inflammation of sinus)

40-49:

Fluid retention (an abnormal accumulation of fluid in the blood)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)

50-59:

Swelling face
Dizziness
Abdominal pain upper
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Heart rate increased
Nausea (feeling of having an urge to vomit)
Pruritus (severe itching of the skin)
Rash
Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints)
Alopecia (absence of hair from areas of the body)

60+:

Drug hypersensitivity
Urticaria (rash of round, red welts on the skin that itch intensely)
Arthropathy
Asthenia (weakness)
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Blood urine present
Burning sensation
Chest discomfort
Chest pain
Chills (felling of cold)

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 9 people, 25.71%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 4 people, 11.43%
High Blood Cholesterol: 4 people, 11.43%
Pain: 3 people, 8.57%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 3 people, 8.57%
Hypersensitivity: 3 people, 8.57%
Back Pain: 3 people, 8.57%
Stress And Anxiety: 2 people, 5.71%
Sleep Disorder: 2 people, 5.71%
Nausea (feeling of having an urge to vomit): 2 people, 5.71%

* Approximation only. Some reports may have incomplete information.

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