Sudafed and Cialis drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Sudafed (pseudoephedrine hydrochloride) and Cialis (tadalafil). Common drug interactions include abdominal pain lower among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Sudafed and Cialis. It is created by eHealthMe based on reports of 44 people who take the same drugs from the FDA, and is updated regularly.

What is Sudafed?

Sudafed has active ingredients of pseudoephedrine hydrochloride. It is often used in nasal congestion. eHealthMe is studying from 12,944 Sudafed users. Check the latest studies of Sudafed.

What is Cialis?

Cialis has active ingredients of tadalafil. It is often used in erection problems. eHealthMe is studying from 28,532 Cialis users. Check the latest studies of Cialis.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

44 people who take Sudafed and Cialis together, and have interactions are studied.

What are the common drug interactions of Sudafed and Cialis, by gender? *:

female:

Abdominal pain lower
Arteritis (inflammation of the walls of arteries)
Arthritis infective (purulent invasion of a joint by an infectious agent which produces arthritis)
Arthropathy
Bone loss
Bone pain
Chills (felling of cold)
Crohn's disease (a condition that causes inflammation of the gastrointestinal tract)
Diarrhoea
Fibromyalgia (a long-term condition which causes pain all over the body)

male:

Chronic kidney disease
Dyspnoea (difficult or laboured respiration)
Hypertension (high blood pressure)
Back pain
Cyst (a closed sac)
Decreased appetite
Diverticulum intestinal (a pouch that is attached to the first part of the small intestine)
Fall
Gastritis (inflammation of stomach)
Hypotension (abnormally low blood pressure)

What are the common drug interactions of Sudafed and Cialis, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Abdominal discomfort
Abdominal distension
Abdominal pain lower
Arteritis (inflammation of the walls of arteries)
Arthralgia (joint pain)
Arthritis infective (purulent invasion of a joint by an infectious agent which produces arthritis)
Arthropathy
Bone loss
Bone pain
Chills (felling of cold)

40-49:

Headache (pain in head)
Irritability
Anal abscess
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Fascial infection (infection in muscle surrounding tissue)
Folliculitis (infection of hair root)
Genital abscess (build up of pus in genital)
Groin abscess (pus in groin)
Hyperglycaemia (high blood sugar)
Hypertension (high blood pressure)

50-59:

Dyspnoea (difficult or laboured respiration)
Feeling cold
Headache (pain in head)
Hypotension (abnormally low blood pressure)
Insomnia (sleeplessness)
Malaise (a feeling of general discomfort or uneasiness)
Muscle fatigue (a condition in which muscles cannot exert their normal force)
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Myalgia (muscle pain)
Nasopharyngitis (inflammation of the nasopharynx)

60+:

Chronic kidney disease
Pneumonia
Basal cell carcinoma (a skin cancer, it rarely metastasizes or kills)
Bone density decreased
Bone neoplasm malignant (cancer of bone)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Bundle branch block right (absence of transmission of electric impulses from the atrioventricular (av) bundle of his to the right ventricle)
Cardiomegaly (increased size of heart than normal)
Cellulitis (infection under the skin)
Chest pain

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 13.64%
Type 2 Diabetes: 5 people, 11.36%
Pain: 5 people, 11.36%
Multiple Myeloma (cancer of the plasma cells): 5 people, 11.36%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 5 people, 11.36%
High Blood Pressure: 5 people, 11.36%
Acne (skin problems that cause pimples): 4 people, 9.09%
Infection: 4 people, 9.09%
Irritable Bowel Syndrome: 4 people, 9.09%
Eye Inflammation: 3 people, 6.82%

* Approximation only. Some reports may have incomplete information.

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