Sudafed and Contac drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Sudafed (pseudoephedrine hydrochloride) and Contac (chlorpheniramine maleate; phenylpropanolamine hydrochloride). Common drug interactions include white blood cell count decreased among females and cerebrovascular accident among males.

The phase IV clinical study analyzes what interactions people have when they take Sudafed and Contac. It is created by eHealthMe based on reports of 31 people who take the same drugs from the FDA, and is updated regularly.

What is Sudafed?

Sudafed has active ingredients of pseudoephedrine hydrochloride. It is often used in nasal congestion. eHealthMe is studying from 12,944 Sudafed users. Check the latest studies of Sudafed.

What is Contac?

Contac has active ingredients of chlorpheniramine maleate; phenylpropanolamine hydrochloride. eHealthMe is studying from 2,877 Contac users. Check the latest studies of Contac.

On Jul, 29, 2026

31 people who take Sudafed and Contac together, and have interactions are studied.

What are the common drug interactions of Sudafed and Contac, by gender? *:

female:

White blood cell count decreased
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Hypertension (high blood pressure)
Back pain
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Transient ischaemic attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow))
Anxiety
Cardiac failure congestive
Headache (pain in head)
Intraventricular haemorrhage (intraventricular bleeding)

male:

Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Blood pressure increased
Cerebral atrophy (decrement in size of brain)
Difficulty in walking
Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Facial palsy (paralysis of face nerve)
Hypertensive crisis
Hypoaesthesia (reduced sense of touch or sensation)
Lacunar infarction (a type of stroke)
Left ventricular hypertrophy (the thickening of the myocardium (muscle) of the left ventricle of the heart)

What are the common drug interactions of Sudafed and Contac, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Blindness unilateral
Blood pressure increased
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)

30-39:

Echocardiogram abnormal
Hypertension (high blood pressure)
Hypokinesia (decreased bodily movement)
Monoparesis (one limb is very weak, but not completely paralyzed)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Cerebral atrophy (decrement in size of brain)
Hypertensive crisis
Left ventricular hypertrophy (the thickening of the myocardium (muscle) of the left ventricle of the heart)
Facial palsy (paralysis of face nerve)
Lacunar infarction (a type of stroke)

40-49:

Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Hypertension (high blood pressure)
Back pain
Cardiac failure congestive
Intraventricular haemorrhage (intraventricular bleeding)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Transient ischaemic attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow))
Aortic valve incompetence
Cerebral haemorrhage (bleeding within the brain)
Haemorrhagic stroke (stroke caused by the rupture of a blood vessel in the brain)

50-59:

Acute myocardial infarction (acute heart attack)
Anxiety
Atherosclerosis (disorder of the arteries)
Back pain
Biliary colic
Blood albumin decreased
Blood alkaline phosphatase nos increased
Blood pressure increased
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Confusion

60+:

Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Anxiety
Aortic valve incompetence
Aortic valve sclerosis (narrowing of the aortic valve)
Blood cholesterol increased
Blood culture positive
Blood pressure systolic increased
Calcinosis (calcium deposits in any soft tissue)
Cardiomegaly (increased size of heart than normal)

What are the existing conditions these people have? *

Nasopharyngitis (inflammation of the nasopharynx): 9 people, 29.03%
Sinus Congestion (blockage of sinus): 3 people, 9.68%

* Approximation only. Some reports may have incomplete information.

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