Sudafed and Keppra drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Sudafed (pseudoephedrine hydrochloride) and Keppra (levetiracetam). Common drug interactions include tachypnoea among females and priapism among males.

The phase IV clinical study analyzes what interactions people have when they take Sudafed and Keppra. It is created by eHealthMe based on reports of 60 people who take the same drugs from the FDA, and is updated regularly.

What is Sudafed?

Sudafed has active ingredients of pseudoephedrine hydrochloride. It is often used in nasal congestion. eHealthMe is studying from 12,944 Sudafed users. Check the latest studies of Sudafed.

What is Keppra?

Keppra has active ingredients of levetiracetam. It is often used in epilepsy. eHealthMe is studying from 73,504 Keppra users. Check the latest studies of Keppra.

On Jul, 12, 2026

60 people who take Sudafed and Keppra together, and have interactions are studied.

What are the common drug interactions of Sudafed and Keppra, by gender? *:

female:

Tachypnoea (a condition of rapid breathing over 20 per minute)
Urinary tract infection
Vasculitis (inflammation of a blood vessel or blood vessels)
Decreased appetite
Dysphagia (a condition in which swallowing is difficult or painful)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Grand mal convulsion (a type of generalized seizure that affects the entire brain)
Hoarseness (changing voice)
Induced labour (prematurely stimulating childbirth in a woman)
Lethargy (tiredness)

male:

Priapism (prolonged and painful erection that can last from several hours up to a few days)
Pyrexia (fever)
Stress
Weight increased
Cold sweat
Constipation
Death
Device failure
Diarrhoea
Drug hypersensitivity

What are the common drug interactions of Sudafed and Keppra, by age (0-1 to 60+)? *:

0-1:

Foetal exposure during pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect)
Pyrexia (fever)

2-9:

n/a

10-19:

n/a

20-29:

Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Drug exposure during pregnancy
Electrocardiogram qt prolonged

30-39:

Constipation
Cough
Dehydration (dryness resulting from the removal of water)
Diarrhoea
Disseminated intravascular coagulation (systemic activation of blood coagulation)
Dry mouth
Dyspnoea (difficult or laboured respiration)
Epistaxis (bleed from the nose)
Erythema multiforme (a type of hypersensitivity reaction)
Escherichia sepsis (bacterial infection by escherichia coli)

40-49:

Epistaxis (bleed from the nose)
Infection
Pre-eclampsia (high blood pressure and significant amounts of protein in the urine of a pregnant woman)
Pyrexia (fever)
Induced labour (prematurely stimulating childbirth in a woman)
Asthenia (weakness)
Fatigue (feeling of tiredness)
Grand mal convulsion (a type of generalized seizure that affects the entire brain)
Pain
Cerebral infarction (less blood supply to brain resulting tissue damage)

50-59:

Fatigue (feeling of tiredness)
Neuropathy peripheral (surface nerve damage)
Pain
Anxiety
Application site pruritus (application site severe itching of the skin)
Blood pressure increased
Conjunctival scar (conjunctival scarring)
Death
Diarrhoea
Drug ineffective

60+:

Nausea (feeling of having an urge to vomit)
Bradycardia (abnormally slow heart action)
Cataract (clouding of the lens inside the eye)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Road traffic accident
Vomiting
Anticonvulsant drug level below therapeutic
Chronic kidney disease
Constipation
Coronary arterial stent insertion

What are the existing conditions these people have? *

Sinusitis (inflammation of sinus): 9 people, 15.00%
Asthma: 9 people, 15.00%
Sinus Congestion (blockage of sinus): 8 people, 13.33%
Insomnia (sleeplessness): 8 people, 13.33%
Bronchitis (inflammation of the mucous membrane in the bronchial tubes): 8 people, 13.33%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 7 people, 11.67%
Depression: 7 people, 11.67%
Post-Traumatic Stress Disorder: 6 people, 10.00%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 8.33%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 4 people, 6.67%

* Approximation only. Some reports may have incomplete information.

Do you take Sudafed and Keppra?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously