Sudafed and Narcan drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Sudafed (pseudoephedrine hydrochloride) and Narcan (naloxone hydrochloride). Common drug interactions include pyrexia among females and dehydration among males.

The phase IV clinical study analyzes what interactions people have when they take Sudafed and Narcan. It is created by eHealthMe based on reports of 19 people who take the same drugs from the FDA, and is updated regularly.

What is Sudafed?

Sudafed has active ingredients of pseudoephedrine hydrochloride. It is often used in nasal congestion. eHealthMe is studying from 12,944 Sudafed users. Check the latest studies of Sudafed.

What is Narcan?

Narcan has active ingredients of naloxone hydrochloride. eHealthMe is studying from 3,687 Narcan users. Check the latest studies of Narcan.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 23, 2026

19 people who take Sudafed and Narcan together, and have interactions are studied.

What are the common drug interactions of Sudafed and Narcan, by gender? *:

female:

Pyrexia (fever)
Bone pain
Cellulitis (infection under the skin)
Drug ineffective
Drug screen positive
Drug withdrawal convulsions
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Eye pain
Fatigue (feeling of tiredness)
Heart transplant

male:

Dehydration (dryness resulting from the removal of water)
Fatigue (feeling of tiredness)
Rash
Renal failure (kidney dysfunction)
Somnolence (a state of near-sleep, a strong desire for sleep)
Ventricular fibrillation (abnormally irregular heart rhythm)
Ventricular tachycardia (rapid heartbeat that originates in one of the lower chambers (the ventricles) of the heart)
Viral infection
Weight increased
Blood pressure decreased

What are the common drug interactions of Sudafed and Narcan, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Cardiomyopathy (weakening of the heart muscle)
Culture urine positive
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Dizziness
Fatigue (feeling of tiredness)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Hypoxia (low oxygen in tissues)
Infusion site infection
Intervertebral disc protrusion (spinal disc protrusion)
Loss of consciousness

50-59:

Necrotising fasciitis (an uncommon life-threatening soft-tissue infection)
Fatigue (feeling of tiredness)
Back pain
Bone pain
Cellulitis (infection under the skin)
Drug dependence
Nausea (feeling of having an urge to vomit)
Pain
Spinal fracture (fracture in one of vertebrae)

60+:

Headache (pain in head)
Herpes zoster
Fatigue (feeling of tiredness)
Joint swelling
Scratch
Skin cancer
Staphylococcal bacteraemia (a bacterial infection of blood)
Tibia fracture (fracture of lower leg bone)
Drug dependence
Drug ineffective

What are the existing conditions these people have? *

Nausea (feeling of having an urge to vomit): 5 people, 26.32%
K-Ras Gene Mutation: 5 people, 26.32%
Pain: 5 people, 26.32%
Colorectal Cancer Stage Iv (cancer of colon and rectal spreads to liver or lung): 5 people, 26.32%
Nausea And Vomiting: 4 people, 21.05%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 21.05%
Muscle Spasms (muscle contraction): 3 people, 15.79%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 3 people, 15.79%
Stress And Anxiety: 3 people, 15.79%
Depression: 2 people, 10.53%

* Approximation only. Some reports may have incomplete information.

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