Sudafed and Requip drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Sudafed (pseudoephedrine hydrochloride) and Requip (ropinirole hydrochloride). Common drug interactions include coronary artery disease among females and peripheral swelling among males.

The phase IV clinical study analyzes what interactions people have when they take Sudafed and Requip. It is created by eHealthMe based on reports of 85 people who take the same drugs from the FDA, and is updated regularly.

What is Sudafed?

Sudafed has active ingredients of pseudoephedrine hydrochloride. It is often used in nasal congestion. eHealthMe is studying from 12,944 Sudafed users. Check the latest studies of Sudafed.

What is Requip?

Requip has active ingredients of ropinirole hydrochloride. It is often used in restless leg syndrome. eHealthMe is studying from 22,950 Requip users. Check the latest studies of Requip.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

85 people who take Sudafed and Requip together, and have interactions are studied.

What are the common drug interactions of Sudafed and Requip, by gender? *:

female:

Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Dizziness
Drug toxicity
Dysuria (painful or difficult urination)
Fall
Flatulence (flatus expelled through the anus)
Hypertension (high blood pressure)
Kidney infection
Megacolon (a very dilated colon)
Memory impairment

male:

Peripheral swelling
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Central auditory processing disorder (cannot process the information they hear in the same way as others do)
Dizziness
Eye inflammation
Faecaloma (hard mass of fecal matter)
Hypoacusis (loss of hearing)
Nerve compression
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Somnolence (a state of near-sleep, a strong desire for sleep)

What are the common drug interactions of Sudafed and Requip, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Anxiety
Fatigue (feeling of tiredness)
Hypertonic bladder (bladder-storage function that causes a sudden urge to urinate)
Intervertebral disc protrusion (spinal disc protrusion)
Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints)
Sciatica (a set of symptoms including pain caused by general compression or irritation of one of five spinal nerve roots of each sciatic nerve)
Synovial cyst (cyst of joint filled with synovial fluid)

30-39:

Drug ineffective
Blood pressure increased
Headache (pain in head)
Palpitations (feelings or sensations that your heart is pounding or racing)
Somnambulism (sleep walking)
Hypersensitivity
Initial insomnia (feeling of inadequate or poor-quality sleep)

40-49:

Asthma
Therapeutic response unexpected
Basal cell carcinoma (a skin cancer, it rarely metastasizes or kills)
Depression
Headache (pain in head)
Influenza like illness
Malaise (a feeling of general discomfort or uneasiness)
Malignant melanoma (skin cancer rises from melancytes)

50-59:

Malaise (a feeling of general discomfort or uneasiness)
Nausea (feeling of having an urge to vomit)
Pollakiuria (abnormally frequent passage of relatively small quantities or urine)
Sepsis (a severe blood infection that can lead to organ failure and death)
Urinary tract infection
Pulmonary sepsis (pus in lungs)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Apnoea (suspension of external breathing)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Attention deficit/hyperactivity disorder

60+:

Nausea (feeling of having an urge to vomit)
Vomiting
Palpitations (feelings or sensations that your heart is pounding or racing)
Sepsis (a severe blood infection that can lead to organ failure and death)
Visual impairment
Somnolence (a state of near-sleep, a strong desire for sleep)
Arthralgia (joint pain)
Atrioventricular block (heart block)
Injury
Pain

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 43 people, 50.59%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 17 people, 20.00%
Drowsiness: 6 people, 7.06%

* Approximation only. Some reports may have incomplete information.

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