Sudafed and Rocephin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Sudafed (pseudoephedrine hydrochloride) and Rocephin (ceftriaxone sodium). Common drug interactions include enteritis among females and pain in extremity among males.

The phase IV clinical study analyzes what interactions people have when they take Sudafed and Rocephin. It is created by eHealthMe based on reports of 48 people who take the same drugs from the FDA, and is updated regularly.

What is Sudafed?

Sudafed has active ingredients of pseudoephedrine hydrochloride. It is often used in nasal congestion. eHealthMe is studying from 12,944 Sudafed users. Check the latest studies of Sudafed.

What is Rocephin?

Rocephin has active ingredients of ceftriaxone sodium. It is often used in infection. eHealthMe is studying from 15,665 Rocephin users. Check the latest studies of Rocephin.

On Jul, 14, 2026

48 people who take Sudafed and Rocephin together, and have interactions are studied.

What are the common drug interactions of Sudafed and Rocephin, by gender? *:

female:

Enteritis (inflammation of the small intestine)
Enterococcal infection
Essential thrombocythaemia (chronic blood cancer)
Exostosis (formation of new bone on the surface of a bone)
Facial neuralgia (pain of face)
Foot fracture
Generalised oedema (swelling all over the body)
Gingival infection (gum infection)
Gingival pain (gum pain)
Gingival swelling (gums swelling)

male:

Pain in extremity
Arthralgia (joint pain)
Abdominal distension
Abdominal pain
Anxiety
Asthenia (weakness)
Back pain
Blood glucose increased
Breath sounds
Catheter site discharge

What are the common drug interactions of Sudafed and Rocephin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Autonomic neuropathy (malfunction of the autonomic nervous system (ans))
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Inappropriate antidiuretic hormone secretion
Status epilepticus (a life-threatening condition in which the brain is in a state of persistent seizure)

20-29:

Anaemia (lack of blood)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Hepatic adenoma (benign liver tumour)
Hypokalaemia (low potassium)
Post procedural haemorrhage (post procedural bleeding)
Thrombophlebitis superficial (swelling (inflammation) of a superficial vein caused by a blood clot)

30-39:

Blood pressure increased

40-49:

Pain
Weight decreased
Abdominal pain upper
Acute interstitial pneumonitis (acute revere lung disease)
Amnestic disorder (group of disorders that involve loss of memories previously established, loss of the ability to create new memories)
Anxiety
Appendiceal abscess
Appendicitis (inflammation of the appendix)
Arthralgia (joint pain)
Asthma

50-59:

Uterine leiomyoma (uterine benign tumour derived from smooth muscle)
Vasculitis (inflammation of a blood vessel or blood vessels)
Vitreous detachment (a condition of the eye in which the vitreous humour separates from the retina)
Wegener's granulomatosis (inflammation of the blood vessels lungs sinuses)
Wound infection staphylococcal
Lumbar spinal stenosis (a medical condition in which the spinal canal narrows and compresses the spinal cord and nerves at the level of the lumbar bone)
Abdominal pain
Anaemia (lack of blood)
Dysphagia (a condition in which swallowing is difficult or painful)
Fatigue (feeling of tiredness)

60+:

Fall
Arthralgia (joint pain)
Tibia fracture (fracture of lower leg bone)
Ageusia (loss of taste functions of the tongue)
Asthenia (weakness)
Asthma
Bronchopulmonary aspergillosis allergic (allergic lung disorder caused by aspergillus fungi)
Chills (felling of cold)
Chronic kidney disease
Constipation

What are the existing conditions these people have? *

Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 24 people, 50.00%
Osteoporosis (bones weak and more likely to break): 24 people, 50.00%
Thrombocytopenia (decrease of platelets in blood): 11 people, 22.92%
Pain: 8 people, 16.67%
High Blood Pressure: 5 people, 10.42%
Constipation: 5 people, 10.42%
Immunodeficiency Common Variable: 4 people, 8.33%
Hypophosphataemia (electrolyte disturbance in which there is an abnormally low level of phosphate in the blood): 4 people, 8.33%
Dehydration (dryness resulting from the removal of water): 4 people, 8.33%
Sinusitis (inflammation of sinus): 3 people, 6.25%

* Approximation only. Some reports may have incomplete information.

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