Sudafed and Septra drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Sudafed (pseudoephedrine hydrochloride) and Septra (sulfamethoxazole; trimethoprim). Common drug interactions include headache among females and arthralgia among males.

The phase IV clinical study analyzes what interactions people have when they take Sudafed and Septra. It is created by eHealthMe based on reports of 48 people who take the same drugs from the FDA, and is updated regularly.

What is Sudafed?

Sudafed has active ingredients of pseudoephedrine hydrochloride. It is often used in nasal congestion. eHealthMe is studying from 12,944 Sudafed users. Check the latest studies of Sudafed.

What is Septra?

Septra has active ingredients of sulfamethoxazole; trimethoprim. It is often used in urinary tract infection. eHealthMe is studying from 10,280 Septra users. Check the latest studies of Septra.

On Jul, 14, 2026

48 people who take Sudafed and Septra together, and have interactions are studied.

What are the common drug interactions of Sudafed and Septra, by gender? *:

female:

Headache (pain in head)
Pyrexia (fever)
Anaemia (lack of blood)
Arthralgia (joint pain)
Back pain
Blood urea increased
Cervicitis (inflammation of the uterine cervix)
Diarrhoea
Dyspnoea (difficult or laboured respiration)
Malaise (a feeling of general discomfort or uneasiness)

male:

Arthralgia (joint pain)
Anaemia (lack of blood)
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Groin pain
Ileitis (inflammation of the ileum)
Inflammatory bowel disease
Irritable bowel syndrome
Multi-organ disorder (multiple organ disease)
Pain in extremity
Abdominal pain upper

What are the common drug interactions of Sudafed and Septra, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Flushing (the warm, red condition of human skin)
Urticaria (rash of round, red welts on the skin that itch intensely)

10-19:

Arthralgia (joint pain)
Contusion (a type of hematoma of tissue in which capillaries)
Conversion disorder (neurological symptoms, such as numbness, blindness, paralysis, or fits without a definable organic cause)
Cough
Ear infection
Ear pain
Foot fracture
Fracture
Inappropriate affect
Joint injury

20-29:

Anaemia (lack of blood)
Arthralgia (joint pain)
Back pain
Cardiac disorder
Chest pain
Crohn's disease (a condition that causes inflammation of the gastrointestinal tract)
Decreased appetite
Fatigue (feeling of tiredness)
Flank pain (a distressing sensation experienced around the lower back and the upper abdomen)
Gastrointestinal disorder (functional problems of gastrointestinal tract)

30-39:

Abdominal pain upper
Drug hypersensitivity
Electrolyte imbalance
Nausea (feeling of having an urge to vomit)
Pruritus (severe itching of the skin)
Rash
Skin lesion
Vomiting
Oral mucosal eruption (a sudden appearing of rash on mucous membrane of mouth)
Oral soft tissue disorder (oral soft tissue disease)

40-49:

Hepatic failure (liver failure)
Intracranial venous sinus thrombosis (presence of thrombosis (a blood clot) in the dural venous sinuses, which drain blood from the brain)
Jugular vein thrombosis (clot in jugular vein)
Alanine aminotransferase increased
Ascites (accumulation of fluid in the abdominal cavity)
Gamma-glutamyltransferase increased
Hepatitis (inflammation of the liver)
Jaundice (a yellowish pigmentation of the skin, the conjunctival membranes)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Vomiting

50-59:

Depression
Diarrhoea
Dyspnoea (difficult or laboured respiration)
Headache (pain in head)
Impaired healing
Malaise (a feeling of general discomfort or uneasiness)
Micturition urgency (urgency to pass the urine)
Myalgia (muscle pain)
Nocturia (the need to get up in the night to urinate)
Osteomyelitis (infection of bone)

60+:

Abdominal pain
Anaemia (lack of blood)
Back pain
Balance disorder
Blood urea increased
Bone disorder
Bone pain
Breast cancer
Breast pain
Bronchiectasis (abnormal widening of the bronchi or their branches, causing a risk of infection)

What are the existing conditions these people have? *

Sarcoidosis (an inflammatory disease that affects multiple organs in the body, but mostly the lungs and lymph glands): 13 people, 27.08%
Menopause (end of monthly cycles in women): 13 people, 27.08%
Anaemia (lack of blood): 13 people, 27.08%
Osteomyelitis (infection of bone): 12 people, 25.00%
Sinusitis (inflammation of sinus): 10 people, 20.83%
Acne (skin problems that cause pimples): 10 people, 20.83%
Gastric Ulcer (stomach ulcer): 8 people, 16.67%
Allergic Sinusitis: 8 people, 16.67%
Ill-Defined Disorder: 3 people, 6.25%

* Approximation only. Some reports may have incomplete information.

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