Sulfasalazine and Pegasys drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Sulfasalazine (sulfasalazine) and Pegasys (peginterferon alfa 2a). Common drug interactions include nausea among females and ascites among males.

The phase IV clinical study analyzes what interactions people have when they take Sulfasalazine and Pegasys. It is created by eHealthMe based on reports of 13 people who take the same drugs from the FDA, and is updated regularly.

What is Sulfasalazine?

Sulfasalazine has active ingredients of sulfasalazine. It is often used in rheumatoid arthritis. eHealthMe is studying from 96,787 Sulfasalazine users. Check the latest studies of Sulfasalazine.

What is Pegasys?

Pegasys has active ingredients of peginterferon alfa 2a. It is often used in hepatitis c. eHealthMe is studying from 57,446 Pegasys users. Check the latest studies of Pegasys.



On Jul, 11, 2026

13 people who take Sulfasalazine and Pegasys together, and have interactions are studied.

Sulfasalazine and Pegasys drug interactions.

What are the common drug interactions of Sulfasalazine and Pegasys, by gender? *:

female:

  1. Nausea (feeling of having an urge to vomit)
  2. Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
  3. Anaemia (lack of blood)
  4. Anger
  5. Decreased appetite
  6. Fatigue (feeling of tiredness)
  7. Loss of consciousness
  8. Pruritus (severe itching of the skin)
  9. White blood cell count decreased
  10. Abdominal distension

male:

  1. Ascites (accumulation of fluid in the abdominal cavity)
  2. Haemolytic anaemia (anaemia due to haemolysis)
  3. Dehydration (dryness resulting from the removal of water)
  4. Diarrhoea
  5. Dizziness
  6. Dyspepsia (indigestion)
  7. Gingival bleeding (bleeding gums)
  8. Haematocrit decreased
  9. Haemoglobin decreased
  10. Loss of consciousness

What are the common drug interactions of Sulfasalazine and Pegasys, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

  1. Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
  2. Anaemia (lack of blood)
  3. Anger
  4. Decreased appetite
  5. Loss of consciousness
  6. Nausea (feeling of having an urge to vomit)
  7. White blood cell count decreased

40-49:

  1. Asthenia (weakness)
  2. Carbon dioxide increased
  3. Haematocrit decreased
  4. Haemoglobin decreased
  5. Loss of consciousness
  6. Red blood cell count decreased
  7. Sinusitis (inflammation of sinus)
  8. White blood cell count decreased

50-59:

  1. Dyspepsia (indigestion)
  2. Nausea (feeling of having an urge to vomit)
  3. Angioneurotic oedema (swelling that occurs just beneath the surface of the skin or mucous membranes)
  4. Arthralgia (joint pain)
  5. Bradycardia (abnormally slow heart action)
  6. Cardiac arrest
  7. Constipation
  8. Dacryostenosis acquired (obstruction of the nasolacrimal duct-acquired)
  9. Diarrhoea
  10. Dysphonia (speech disorder attributable to a disorder of phonation)

60+:

  1. Abdominal distension
  2. Ageusia (loss of taste functions of the tongue)
  3. Headache (pain in head)
  4. Platelet count decreased
  5. Pruritus (severe itching of the skin)
  6. Tremor (trembling or shaking movements in one or more parts of your body)
  7. Visual impairment
  8. Weight decreased
  9. Anorectal discomfort
  10. Aphagia (inability or refusal to swallow)

What are the existing conditions these people have? *

  1. Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 2 people, 15.38%
  2. Indigestion: 1 person, 7.69%
  3. Headache (pain in head): 1 person, 7.69%
  4. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 7.69%
  5. Drowsiness: 1 person, 7.69%
  6. Colitis (inflammation of colon): 1 person, 7.69%
  7. Cardiac Disorder: 1 person, 7.69%

* Approximation only. Some reports may have incomplete information.

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Sulfasalazine and Pegasys:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Sulfasalazine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Pegasys:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Sulfasalazine and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Pegasys and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on sulfasalazine and peginterferon alfa 2a (the active ingredients of Sulfasalazine and Pegasys, respectively), and Sulfasalazine and Pegasys (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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