Sulindac and Effexor drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Sulindac (sulindac) and Effexor (venlafaxine hydrochloride). Common drug interactions include gastrooesophageal reflux disease among females and back pain among males.

The phase IV clinical study analyzes what interactions people have when they take Sulindac and Effexor. It is created by eHealthMe based on reports of 91 people who take the same drugs from the FDA, and is updated regularly.

What is Sulindac?

Sulindac has active ingredients of sulindac. It is often used in rheumatoid arthritis. eHealthMe is studying from 3,824 Sulindac users. Check the latest studies of Sulindac.

What is Effexor?

Effexor has active ingredients of venlafaxine hydrochloride. It is often used in depression. eHealthMe is studying from 99,496 Effexor users. Check the latest studies of Effexor.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

91 people who take Sulindac and Effexor together, and have interactions are studied.

What are the common drug interactions of Sulindac and Effexor, by gender? *:

female:

Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
General physical health deterioration (weak health status)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Joint dislocation (a joint position is changed from normal position)
Osteopenia (a condition where bone mineral density is lower than normal)
Resorption bone increased
Abdominal pain
Road traffic accident
Diarrhoea
Obesity (having too much body fat)

male:

Back pain
Fatigue (feeling of tiredness)
Type 2 diabetes mellitus
Dry eye (lack of adequate tears)
Alopecia (absence of hair from areas of the body)
Angina pectoris (chest pain due to ischemia of the heart muscle)
Ankylosing spondylitis (type of arthritis affecting the spine)
Arthralgia (joint pain)
Bone disorder
Calcium deficiency (lack of calcium)

What are the common drug interactions of Sulindac and Effexor, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diabetes mellitus inadequate control

40-49:

Biliary dyskinesia (motility disorder that affects the gallbladder and sphincter of oddi)
Chest discomfort
Cholecystitis chronic (long lasting infection of gallbladder)
Dyspnoea (difficult or laboured respiration)
Injury
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Muscle spasms (muscle contraction)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Nausea (feeling of having an urge to vomit)
Pain in extremity

50-59:

Acute sinusitis
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Constipation
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)
Dysphagia (a condition in which swallowing is difficult or painful)
Fall
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Gigantism (excessive growth and height)

60+:

Fall
Ankle fracture
Resorption bone increased
Road traffic accident
Rotator cuff syndrome (a spectrum of conditions affecting the rotator cuff tendons of the shoulder)
Skin ulcer
Ulnar neuritis (inflammation or compression of the ulnar nerve)
Wound infection pseudomonas
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Cataract (clouding of the lens inside the eye)

What are the existing conditions these people have? *

Osteoporosis (bones weak and more likely to break): 20 people, 21.98%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 15 people, 16.48%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 11 people, 12.09%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 9 people, 9.89%
Pain: 7 people, 7.69%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 5.49%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 5 people, 5.49%

* Approximation only. Some reports may have incomplete information.

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