Sulindac and Leflunomide drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Sulindac (sulindac) and Leflunomide (leflunomide). Common drug interactions include rash among females and drug ineffective among males.

The phase IV clinical study analyzes what interactions people have when they take Sulindac and Leflunomide. It is created by eHealthMe based on reports of 89 people who take the same drugs from the FDA, and is updated regularly.

What is Sulindac?

Sulindac has active ingredients of sulindac. It is often used in rheumatoid arthritis. eHealthMe is studying from 3,824 Sulindac users. Check the latest studies of Sulindac.

What is Leflunomide?

Leflunomide has active ingredients of leflunomide. It is often used in rheumatoid arthritis. eHealthMe is studying from 82,105 Leflunomide users. Check the latest studies of Leflunomide.

On Jul, 14, 2026

89 people who take Sulindac and Leflunomide together, and have interactions are studied.

Sulindac and Leflunomide drug interactions.

What are the common drug interactions of Sulindac and Leflunomide, by gender? *:

female:

Rash
Rheumatoid nodule (a local swelling or tissue lump with rheumatoid disease)
Upper respiratory tract infection
Abdominal discomfort
Abdominal sepsis (abdominal infection)
Accidental exposure
Alanine aminotransferase increased
Anxiety
Asthenopia (eyestrain-tiredness of the eyes caused by prolonged close work by a person with an uncorrected vision problem)
Bacterial infection

male:

Drug ineffective
Infection
Weight increased
Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)
Anaemia (lack of blood)
C-reactive protein increased
Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)
Diarrhoea
Drug intolerance (drug sensitivity)
Dysarthria (speech disorder)

What are the common drug interactions of Sulindac and Leflunomide, by age (0-1 to 60+)? *:

0-1:

Foetal exposure during pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect)

2-9:

n/a

10-19:

Lung disorder (lung disease)
Lymphadenopathy (disease or enlargement of lymph nodes)
Renal impairment (severely reduced kidney function)

20-29:

n/a

30-39:

Anxiety
Arthralgia (joint pain)
Chest discomfort
Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Hypertension (high blood pressure)
Nausea (feeling of having an urge to vomit)
Peripheral swelling
Pharyngitis (inflammation of the pharynx, causing a sore throat)

40-49:

Drug hypersensitivity
Hepatic enzyme increased
Rash
Alanine aminotransferase increased
Alopecia (absence of hair from areas of the body)
Asthenopia (eyestrain-tiredness of the eyes caused by prolonged close work by a person with an uncorrected vision problem)
Burning sensation
Disability
Drug ineffective
Drug intolerance (drug sensitivity)

50-59:

Malaise (a feeling of general discomfort or uneasiness)
Muscular weakness (muscle weakness)
Myalgia (muscle pain)
Nerve compression
Pain in extremity
Palpitations (feelings or sensations that your heart is pounding or racing)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Peripheral swelling
Pneumonia
Pruritus generalised (generalized itching)

60+:

Discomfort
Osteoporosis (bones weak and more likely to break)
Arthralgia (joint pain)
Arthropathy
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Bacterial sepsis
Bone lesion (bone with abnormalities. bone lesions can result from growth formations, infections, or injuries)
Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)
Cardiomegaly (increased size of heart than normal)
Cerebral infarction (less blood supply to brain resulting tissue damage)

What are the existing conditions these people have? *

Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 10 people, 11.24%

* Approximation only. Some reports may have incomplete information.

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