Sulindac and Prozac drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Sulindac (sulindac) and Prozac (fluoxetine hydrochloride). Common drug interactions include musculoskeletal chest pain among females and renal failure among males.

The phase IV clinical study analyzes what interactions people have when they take Sulindac and Prozac. It is created by eHealthMe based on reports of 78 people who take the same drugs from the FDA, and is updated regularly.

What is Sulindac?

Sulindac has active ingredients of sulindac. It is often used in rheumatoid arthritis. eHealthMe is studying from 3,824 Sulindac users. Check the latest studies of Sulindac.

What is Prozac?

Prozac has active ingredients of fluoxetine hydrochloride. It is often used in depression. eHealthMe is studying from 82,988 Prozac users. Check the latest studies of Prozac.

On Jul, 19, 2026

78 people who take Sulindac and Prozac together, and have interactions are studied.

What are the common drug interactions of Sulindac and Prozac, by gender? *:

female:

Musculoskeletal chest pain (pain in chest muscle or nerve or bones)
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Myopia (difficult to see objects that are far away)
Nausea (feeling of having an urge to vomit)
Neck pain
Onychomycosis (fungal infection of the nail)
Osteopenia (a condition where bone mineral density is lower than normal)
Pancreatitis (inflammation of pancreas)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Presbyopia (a condition in which the lens of the eye loses its ability to focus, making it difficult to see objects up close)

male:

Renal failure (kidney dysfunction)
Chronic kidney disease
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Convulsions (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled of muscles contract and relax rapidly and repeatedly)
Death
Drug level increased
Hallucination (an experience involving the perception of something not present)
Hyperhidrosis (abnormally increased sweating)
Hypophagia (reduced food intake)
Kidney infection

What are the common drug interactions of Sulindac and Prozac, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Chronic kidney disease
Renal failure (kidney dysfunction)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Bone disorder
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diabetes mellitus inadequate control

40-49:

Chronic kidney disease
Renal injury (kidney injury)
Nephrogenic anaemia (anaemia due to kidney disease)
Renal failure (kidney dysfunction)
Convulsions (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled of muscles contract and relax rapidly and repeatedly)
Bacterial test positive
Blood alkaline phosphatase nos increased
Blood bilirubin increased
Blood cholesterol increased
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)

50-59:

Glaucoma (increased fluid pressure in the eye with vision loss)
Glycosuria (excretion of glucose into the urine)
Hyperkeratosis (thickening of the outer layer of the skin)
Incontinence (lack of moderation or self-control)
Libido decreased (loss of interest in sex)
Musculoskeletal chest pain (pain in chest muscle or nerve or bones)
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Myopia (difficult to see objects that are far away)
Onychomycosis (fungal infection of the nail)
Osteopenia (a condition where bone mineral density is lower than normal)

60+:

Arthralgia (joint pain)
Abdominal pain
Upper limb fracture
Blood pressure increased
Hepatotoxicity (chemical-driven liver damage)
Joint swelling
Kidney infection
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Nodal osteoarthritis (a more painful form of osteoarthritis a affecting the end joints of fingers is called nodal osteoarthritis)
Oxygen saturation decreased

What are the existing conditions these people have? *

Stress And Anxiety: 12 people, 15.38%
Pain: 10 people, 12.82%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 10 people, 12.82%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 9 people, 11.54%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 7 people, 8.97%
High Blood Pressure: 7 people, 8.97%
Hypovitaminosis (any of several diseases caused by deficiency of one or more vitamins): 5 people, 6.41%
Bipolar Disorder (mood disorder): 5 people, 6.41%
Asthma: 4 people, 5.13%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 4 people, 5.13%

* Approximation only. Some reports may have incomplete information.

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