Sumatriptan succinate and Methotrexate sodium drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Sumatriptan succinate (sumatriptan succinate) and Methotrexate sodium (methotrexate sodium). Common drug interactions include drug ineffective among females and nonspecific reaction among males.

The phase IV clinical study analyzes what interactions people have when they take Sumatriptan succinate and Methotrexate sodium. It is created by eHealthMe based on reports of 91 people who take the same drugs from the FDA, and is updated regularly.

What is Sumatriptan succinate?

Sumatriptan succinate has active ingredients of sumatriptan succinate. It is often used in migraine. eHealthMe is studying from 9,731 Sumatriptan succinate users. Check the latest studies of Sumatriptan succinate.

What is Methotrexate sodium?

Methotrexate sodium has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. eHealthMe is studying from 97,679 Methotrexate sodium users. Check the latest studies of Methotrexate sodium.

On Jul, 09, 2026

91 people who take Sumatriptan succinate and Methotrexate sodium together, and have interactions are studied.

Sumatriptan succinate and Methotrexate sodium drug interactions.

What are the common drug interactions of Sumatriptan Succinate and Methotrexate Sodium, by gender? *:

female:

Drug ineffective
Drug intolerance (drug sensitivity)
Hypertension (high blood pressure)
Arthralgia (joint pain)
Asthma
Chronic kidney disease
Depression
Endometriosis (appearance of endometrial tissue outside the uterus and causing pelvic pain)
Joint swelling
Psoriasis (immune-mediated disease that affects the skin)

male:

Nonspecific reaction (unspecified reaction)
Blood glucose increased
Kidney infection
Pain
Fatigue (feeling of tiredness)
Renal failure (kidney dysfunction)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Cardiac disorder
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Fluid retention (an abnormal accumulation of fluid in the blood)

What are the common drug interactions of Sumatriptan Succinate and Methotrexate Sodium, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Drug screen false positive
Vomiting

30-39:

n/a

40-49:

Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Decreased interest
Erythema (redness of the skin)
Immunodeficiency
Injection site burning
Injection site erythema (redness at injection site)
Mobility decreased (ability to move is reduced)
Nausea (feeling of having an urge to vomit)
Pain

50-59:

Asthma
Chronic kidney disease
Depression
Drug ineffective
Drug intolerance (drug sensitivity)
Endometriosis (appearance of endometrial tissue outside the uterus and causing pelvic pain)
Hypertension (high blood pressure)
Psoriasis (immune-mediated disease that affects the skin)
Drug specific antibody present
Abdominal distension

60+:

Fatigue (feeling of tiredness)
Arthralgia (joint pain)
Hypertension (high blood pressure)
Therapeutic response decreased (less preventive response)
Nonspecific reaction (unspecified reaction)
Blood glucose increased
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cardiac disorder
Renal failure (kidney dysfunction)

What are the existing conditions these people have? *

Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 23 people, 25.27%
Parkinson's Disease: 7 people, 7.69%

* Approximation only. Some reports may have incomplete information.

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