Sumatriptan and Hydroxyzine pamoate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Sumatriptan (sumatriptan succinate) and Hydroxyzine pamoate (hydroxyzine pamoate). Common drug interactions include gastrooesophageal reflux disease among females and emotional distress among males.

The phase IV clinical study analyzes what interactions people have when they take Sumatriptan and Hydroxyzine pamoate. It is created by eHealthMe based on reports of 53 people who take the same drugs from the FDA, and is updated regularly.

What is Sumatriptan?

Sumatriptan has active ingredients of sumatriptan succinate. It is often used in migraine. eHealthMe is studying from 18,159 Sumatriptan users. Check the latest studies of Sumatriptan.

What is Hydroxyzine pamoate?

Hydroxyzine pamoate has active ingredients of hydroxyzine pamoate. It is often used in stress and anxiety. eHealthMe is studying from 4,252 Hydroxyzine pamoate users. Check the latest studies of Hydroxyzine pamoate.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 21, 2026

53 people who take Sumatriptan and Hydroxyzine pamoate together, and have interactions are studied.

Sumatriptan and Hydroxyzine pamoate drug interactions.

What are the common drug interactions of Sumatriptan and Hydroxyzine Pamoate, by gender? *:

female:

Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Headache (pain in head)
Infected cyst
Infection
Infusion site reaction
Insomnia (sleeplessness)
Mania (a state of abnormally elevated or irritable mood)
Nephrolithiasis (calculi in the kidneys)
Neuropathy peripheral (surface nerve damage)
Oedema (fluid collection in tissue)

male:

Emotional distress
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Blood creatinine increased
Bronchitis chronic (inflammation of the mucous membrane in the bronchial tubes- chronic)
Compulsive shopping
Depression
Dermatillomania (skin picking disorders)
Diarrhoea
Dysphagia (a condition in which swallowing is difficult or painful)
Eating disorder

What are the common drug interactions of Sumatriptan and Hydroxyzine Pamoate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Pulmonary embolism (blockage of the main artery of the lung)

30-39:

Chronic kidney disease
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Arthralgia (joint pain)
Bankruptcy
Bipolar i disorder (mood disorder that is characterized by at least one manic or mixed episode)
Bronchitis chronic (inflammation of the mucous membrane in the bronchial tubes- chronic)
Compulsive shopping
Dermatillomania (skin picking disorders)
Dysphagia (a condition in which swallowing is difficult or painful)

40-49:

Conjunctivitis allergic (inflammation of the conjunctiva due to allergy)
Constipation
Diarrhoea
Dry skin
Dyslipidaemia (abnormal amount of lipids)
Dysphagia (a condition in which swallowing is difficult or painful)
Escherichia urinary tract infection (urinary tract infection by escherichia coli)
Fungal infection
Gastric disorder (disease of stomach)
Gastrointestinal disorder (functional problems of gastrointestinal tract)

50-59:

Chronic kidney disease
Renal impairment (severely reduced kidney function)
Abscess (pus)
Drug abuse
Drug abuser
Hepatic cirrhosis (chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue)
Hospitalisation
Overdose
Staphylococcal bacteraemia (a bacterial infection of blood)
Alcohol poisoning

60+:

Drug ineffective
Cardiac failure congestive
Emotional distress
Joint injury
Osteopenia (a condition where bone mineral density is lower than normal)
Osteoporosis (bones weak and more likely to break)
Pain
Renal failure (kidney dysfunction)
Renal impairment (severely reduced kidney function)
Oedema peripheral (superficial swelling)

What are the existing conditions these people have? *

Pain: 14 people, 26.42%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 13 people, 24.53%
Itching: 9 people, 16.98%
High Blood Pressure: 7 people, 13.21%
Nausea (feeling of having an urge to vomit): 6 people, 11.32%
Constipation: 6 people, 11.32%
Immunodeficiency Common Variable: 5 people, 9.43%
Diabetes: 5 people, 9.43%
Hiv Infection: 4 people, 7.55%
Rashes (redness): 4 people, 7.55%

* Approximation only. Some reports may have incomplete information.

Do you take Sumatriptan and Hydroxyzine pamoate?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously