Sumatriptan and Mestinon drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Sumatriptan (sumatriptan succinate) and Mestinon (pyridostigmine bromide). Common drug interactions include nausea among females and asthenia among males.

The phase IV clinical study analyzes what interactions people have when they take Sumatriptan and Mestinon. It is created by eHealthMe based on reports of 30 people who take the same drugs from the FDA, and is updated regularly.

What is Sumatriptan?

Sumatriptan has active ingredients of sumatriptan succinate. It is often used in migraine. eHealthMe is studying from 18,159 Sumatriptan users. Check the latest studies of Sumatriptan.

What is Mestinon?

Mestinon has active ingredients of pyridostigmine bromide. It is often used in myasthenia gravis. eHealthMe is studying from 5,948 Mestinon users. Check the latest studies of Mestinon.

On Jul, 09, 2026

30 people who take Sumatriptan and Mestinon together, and have interactions are studied.

Sumatriptan and Mestinon drug interactions.

What are the common drug interactions of Sumatriptan and Mestinon, by gender? *:

female:

Nausea (feeling of having an urge to vomit)
Fatigue (feeling of tiredness)
Activated partial thromboplastin time prolonged
Alanine aminotransferase increased
Aspartate aminotransferase increased
B-lymphocyte count decreased
Blood albumin decreased
Blood bilirubin increased
Blood calcium decreased
Blood creatine phosphokinase increased

male:

Asthenia (weakness)
Myalgia (muscle pain)
Muscle spasms (muscle contraction)
Prostatomegaly (enlargement of the prostate)
Therapeutic response unexpected
Urine flow decreased
Vitamin b complex deficiency
Vitamin b12 deficiency
Vitamin d deficiency
Pain

What are the common drug interactions of Sumatriptan and Mestinon, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Asthenia (weakness)
Maculopathy (a condition or disease of the macula, the small spot in the retina where vision is keenest)
Myalgia (muscle pain)
Pain
Tremor (trembling or shaking movements in one or more parts of your body)
Asthenopia (eyestrain-tiredness of the eyes caused by prolonged close work by a person with an uncorrected vision problem)
Blood electrolytes decreased
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Dizziness
Dysstasia (difficulty in standing)

40-49:

Pneumococcal sepsis (pneumococcal sepsis is a serious medical condition where bacteria, specifically streptococcus pneumoniae)
Pneumonia viral
Sepsis (a severe blood infection that can lead to organ failure and death)
Chronic kidney disease
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hyperhidrosis (abnormally increased sweating)
Pain
Palpitations (feelings or sensations that your heart is pounding or racing)
Vertigo
Withdrawal syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance)

50-59:

Nausea (feeling of having an urge to vomit)
Fatigue (feeling of tiredness)
Concussion (short loss of normal brain function in response to a head injury)
Craniocerebral injury (injury to cranium and brain)
Dysphagia (a condition in which swallowing is difficult or painful)
Palpitations (feelings or sensations that your heart is pounding or racing)
Post concussion syndrome
Stress
Syncope (loss of consciousness with an inability to maintain postural tone)
Abdominal pain

60+:

Activated partial thromboplastin time prolonged
Alanine aminotransferase increased
Blood fibrinogen increased
Blood magnesium increased
Blood osmolarity increased
Blood phosphorus increased
Blood potassium increased
Blood prolactin increased
Blood thyroid stimulating hormone decreased
Blood urea increased

What are the existing conditions these people have? *

Cataplexy (loss of muscle tone accompanied by full conscious awareness): 5 people, 16.67%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 5 people, 16.67%
Ankylosing Spondylitis (type of arthritis affecting the spine): 4 people, 13.33%
Pain: 4 people, 13.33%
Thymoma (a tumour originating from the epithelial cells of the thymus): 3 people, 10.00%
Stress And Anxiety: 3 people, 10.00%
Asthma: 3 people, 10.00%
Nausea (feeling of having an urge to vomit): 3 people, 10.00%
Metastases To Pleura (cancer spreads to pleura): 3 people, 10.00%
Depression: 3 people, 10.00%

* Approximation only. Some reports may have incomplete information.

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