Sumatriptan and Nifedipine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Sumatriptan (sumatriptan succinate) and Nifedipine (nifedipine). Common drug interactions include gastrointestinal disorder among females and neuropathy peripheral among males.

The phase IV clinical study analyzes what interactions people have when they take Sumatriptan and Nifedipine. It is created by eHealthMe based on reports of 72 people who take the same drugs from the FDA, and is updated regularly.

What is Sumatriptan?

Sumatriptan has active ingredients of sumatriptan succinate. It is often used in migraine. eHealthMe is studying from 18,159 Sumatriptan users. Check the latest studies of Sumatriptan.

What is Nifedipine?

Nifedipine has active ingredients of nifedipine. It is often used in high blood pressure. eHealthMe is studying from 53,459 Nifedipine users. Check the latest studies of Nifedipine.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Jul, 03, 2026

72 people who take Sumatriptan and Nifedipine together, and have interactions are studied.

Sumatriptan and Nifedipine drug interactions.

What are the common drug interactions of Sumatriptan and Nifedipine, by gender? *:

female:

Gastrointestinal disorder (functional problems of gastrointestinal tract)
Haemangioma of liver (noncancerous, abnormally dense collections of dilated small blood vessels that may occur in liver)
Infective spondylitis (infective inflammation of a spinal joint; characterized by pain and stiffness)
Lumbosacral plexus injury (injury to lumbosacral nerve branching network)
Major depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings)
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Nephrolithiasis (calculi in the kidneys)
Osteomyelitis (infection of bone)
Osteoporosis (bones weak and more likely to break)
Post procedural complication

male:

Neuropathy peripheral (surface nerve damage)
Weight fluctuation
Nephrolithiasis (calculi in the kidneys)
Oedema peripheral (superficial swelling)
Tachypnoea (a condition of rapid breathing over 20 per minute)
Chronic kidney disease
Drug exposure during pregnancy
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Nephrogenic anaemia (anaemia due to kidney disease)
Premature labour

What are the common drug interactions of Sumatriptan and Nifedipine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Behcet's syndrome (involves inflammation of the blood vessels)
Drug hypersensitivity
Nausea (feeling of having an urge to vomit)
Pain
Pancreatitis acute (sudden inflammation of pancreas)
Vomiting
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Weight fluctuation
Abdominal infection
Chronic kidney disease

40-49:

Abdominal discomfort
Cluster headache (one-sided head pain with tearing)
Acne (skin problems that cause pimples)
Bladder disorder
Breast cancer
Dehydration (dryness resulting from the removal of water)
Depression
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Headache (pain in head)
Infective spondylitis (infective inflammation of a spinal joint; characterized by pain and stiffness)

50-59:

Chronic kidney disease
Renal failure (kidney dysfunction)
Renal tubular necrosis (death of kidney tubules)
Anuria (failure of the kidneys to produce urine)
Basal cell carcinoma (a skin cancer, it rarely metastasizes or kills)
Blood iron decreased
Crest syndrome (thick, dry and fibrous skin)
Headache (pain in head)
Kidney transplant rejection
Malignant melanoma (skin cancer rises from melancytes)

60+:

Chronic kidney disease
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Decreased appetite
Drug ineffective
Dyspnoea (difficult or laboured respiration)
Epistaxis (bleed from the nose)
Generalised oedema (swelling all over the body)
Headache (pain in head)
Heart rate increased
Hypersensitivity

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 24 people, 33.33%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 24 people, 33.33%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 8 people, 11.11%
Infection: 7 people, 9.72%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 4 people, 5.56%
Ill-Defined Disorder: 4 people, 5.56%
Headache (pain in head): 4 people, 5.56%

* Approximation only. Some reports may have incomplete information.

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