Sumatriptan and Nyquil drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Sumatriptan (sumatriptan succinate) and Nyquil (acetaminophen / dextromethorphan / doxylamine / pseudoephedrine). Common drug interactions include gastrooesophageal reflux disease among females and craniosynostosis among males.

The phase IV clinical study analyzes what interactions people have when they take Sumatriptan and Nyquil. It is created by eHealthMe based on reports of 18 people who take the same drugs from the FDA, and is updated regularly.

What is Sumatriptan?

Sumatriptan has active ingredients of sumatriptan succinate. It is often used in migraine. eHealthMe is studying from 18,159 Sumatriptan users. Check the latest studies of Sumatriptan.

What is Nyquil?

Nyquil has active ingredients of acetaminophen / dextromethorphan / doxylamine / pseudoephedrine. It is often used in cold symptoms. eHealthMe is studying from 2,240 Nyquil users. Check the latest studies of Nyquil.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 04, 2026

18 people who take Sumatriptan and Nyquil together, and have interactions are studied.

Sumatriptan and Nyquil drug interactions.

What are the common drug interactions of Sumatriptan and Nyquil, by gender? *:

female:

Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hiatus hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm)
Therapeutic response unexpected
Alopecia (absence of hair from areas of the body)
Inflammation
Sedation
Asthenia (weakness)
Loss of consciousness
Blood pressure fluctuation
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)

male:

Craniosynostosis (a baby is born with an abnormally shaped skull or develops one during growth)
Hypoaesthesia oral (reduced sense of touch or sensation in mouth)
Infection
Nephrolithiasis (calculi in the kidneys)
Paraesthesia oral (sensation of tingling, tickling, prickling, pricking, or burning of a person's oral with no apparent long-term physical effect)
Premature baby

What are the common drug interactions of Sumatriptan and Nyquil, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Alopecia (absence of hair from areas of the body)
Inflammation
Sinusitis (inflammation of sinus)
Sedation
Blood pressure fluctuation
Blood pressure increased
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Dyskinesia (abnormality or impairment of voluntary movement)
Loss of consciousness
Rib fracture

60+:

Bipolar disorder (mood disorder)
Blood pressure increased
Blood folate decreased
Cerebral disorder (brain disease)
Confusional state
Dyspepsia (indigestion)
Ear infection
Escherichia infection (bacterial infection by escherichia coli)
Fall
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 12 people, 66.67%
Pain: 4 people, 22.22%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 3 people, 16.67%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 11.11%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 11.11%
Drowsiness: 2 people, 11.11%
Stress And Anxiety: 1 person, 5.56%
Back Pain: 1 person, 5.56%
Balance Disorder: 1 person, 5.56%
Bipolar Disorder (mood disorder): 1 person, 5.56%

* Approximation only. Some reports may have incomplete information.

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