Sunosi and Oxycodone and acetaminophen drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Sunosi (solriamfetol) and Oxycodone and acetaminophen (acetaminophen; oxycodone hydrochloride). Common drug interactions include sleep apnoea syndrome among females and sleep apnoea syndrome among males.

The phase IV clinical study analyzes what interactions people have when they take Sunosi and Oxycodone and acetaminophen. It is created by eHealthMe based on reports of 34 people who take the same drugs from the FDA, and is updated regularly.

What is Sunosi?

Sunosi has active ingredients of solriamfetol. eHealthMe is studying from 2,936 Sunosi users. Check the latest studies of Sunosi.

What is Oxycodone and acetaminophen?

Oxycodone and acetaminophen has active ingredients of acetaminophen; oxycodone hydrochloride. It is often used in pain. eHealthMe is studying from 14,467 Oxycodone and acetaminophen users. Check the latest studies of Oxycodone and acetaminophen.

On Jul, 04, 2026

34 people who take Sunosi and Oxycodone and acetaminophen together, and have interactions are studied.

Sunosi and Oxycodone and acetaminophen drug interactions.

What are the common drug interactions of Sunosi and Oxycodone And Acetaminophen, by gender? *:

female:

Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Weight decreased
Nocturia (the need to get up in the night to urinate)
Depression
Nausea (feeling of having an urge to vomit)
Blood glucose fluctuation
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Fibromyalgia (a long-term condition which causes pain all over the body)
Irritable bowel syndrome

male:

Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Chronic inflammatory demyelinating polyradiculoneuropathy (long lasting infection of nerves outside brain and spinal cord)
Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Hangover
Hypersensitivity
Hypotension (abnormally low blood pressure)
Palpitations (feelings or sensations that your heart is pounding or racing)
Somnolence (a state of near-sleep, a strong desire for sleep)
Surgery
Vitamin b12 increased

What are the common drug interactions of Sunosi and Oxycodone And Acetaminophen, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Abdominal discomfort
Anxiety
Hepatic steatosis (fatty liver disease)
Kidney infection
Renal impairment (severely reduced kidney function)
Sepsis (a severe blood infection that can lead to organ failure and death)
Somnolence (a state of near-sleep, a strong desire for sleep)
Surgery

40-49:

Sleep terror (felling of terror in sleep)
Chronic inflammatory demyelinating polyradiculoneuropathy (long lasting infection of nerves outside brain and spinal cord)
Drug hypersensitivity
Drug ineffective
Muscle spasms (muscle contraction)
Shoulder operation
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Weight increased
Abdominal pain
Blood pressure increased

50-59:

Depression
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Nausea (feeling of having an urge to vomit)
Nocturia (the need to get up in the night to urinate)
Obesity (having too much body fat)
Osteoporosis (bones weak and more likely to break)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Tardive dyskinesia (a disorder that involves involuntary movements)
Fall

60+:

Limb injury
Lower limb fracture
Muscular weakness (muscle weakness)
Nausea (feeling of having an urge to vomit)
Onychomycosis (fungal infection of the nail)
Pain in extremity
Renal impairment (severely reduced kidney function)
Skin ulcer
Weight decreased

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 33 people, 97.06%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 22 people, 64.71%
Drowsiness: 16 people, 47.06%
Hypertonic Bladder (bladder-storage function that causes a sudden urge to urinate): 4 people, 11.76%
Indigestion: 3 people, 8.82%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 3 people, 8.82%

* Approximation only. Some reports may have incomplete information.

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