Sustiva and Dilantin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Sustiva (efavirenz) and Dilantin (phenytoin sodium). Common drug interactions include haemoglobin decreased among females and angina pectoris among males.

The phase IV clinical study analyzes what interactions people have when they take Sustiva and Dilantin. It is created by eHealthMe based on reports of 16 people who take the same drugs from the FDA, and is updated regularly.

What is Sustiva?

Sustiva has active ingredients of efavirenz. It is often used in hiv infection. eHealthMe is studying from 11,040 Sustiva users. Check the latest studies of Sustiva.

What is Dilantin?

Dilantin has active ingredients of phenytoin sodium. It is often used in epilepsy. eHealthMe is studying from 20,858 Dilantin users. Check the latest studies of Dilantin.

On Jul, 10, 2026

16 people who take Sustiva and Dilantin together, and have interactions are studied.

What are the common drug interactions of Sustiva and Dilantin, by gender? *:

female:

Haemoglobin decreased
Pancreatitis necrotising (inflammation of the pancreas cause death of tissue in pancreas)
Vomiting
Abdominal pain
Abdominal tenderness
Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight)
Asthenia (weakness)
Ataxia (loss of full control of bodily movements)
Bronchospasm (spasm of bronchial smooth muscle producing narrowing of the bronchi)
Confusion

male:

Angina pectoris (chest pain due to ischemia of the heart muscle)
Arthropathy
Pharyngolaryngeal pain
Activities of daily living impaired
Cardiac failure congestive
Chest discomfort
Congestive cardiomyopathy (weakening of heart muscle)
Convulsions (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled of muscles contract and relax rapidly and repeatedly)
Coronary artery occlusion (complete obstruction of blood flow in a coronary artery)
Ejaculation disorder

What are the common drug interactions of Sustiva and Dilantin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Ataxia (loss of full control of bodily movements)
Confusion
Dermatitis exfoliative (widespread scaling of the skin, often with itching (pruritus), skin redness (erythroderma), and hair loss)
Drug toxicity
Ejaculation disorder
Erythema multiforme (a type of hypersensitivity reaction)
Nausea (feeling of having an urge to vomit)
Priapism (prolonged and painful erection that can last from several hours up to a few days)
Rash pruritic (redness with itching)
Stevens johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)

40-49:

Nasopharyngitis (inflammation of the nasopharynx)
Obstruction
Pharyngolaryngeal pain
Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight)
Asthenia (weakness)
Chest discomfort
Congestive cardiomyopathy (weakening of heart muscle)
Coronary artery occlusion (complete obstruction of blood flow in a coronary artery)
Diarrhoea
Intervertebral disc degeneration (spinal disc degeneration)

50-59:

Activities of daily living impaired
International normalised ratio increased

60+:

n/a

What are the existing conditions these people have? *

Joint Pain: 2 people, 12.50%
Hiv Infection: 1 person, 6.25%
Diabetes: 1 person, 6.25%
Bleeding Disorders: 1 person, 6.25%

* Approximation only. Some reports may have incomplete information.

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