Symbyax and Actos drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Symbyax (fluoxetine hydrochloride; olanzapine) and Actos (pioglitazone hydrochloride). Common drug interactions include carpal tunnel decompression among females and weight increased among males.

The phase IV clinical study analyzes what interactions people have when they take Symbyax and Actos. It is created by eHealthMe based on reports of 30 people who take the same drugs from the FDA, and is updated regularly.

What is Symbyax?

Symbyax has active ingredients of fluoxetine hydrochloride; olanzapine. It is often used in depression. eHealthMe is studying from 1,449 Symbyax users. Check the latest studies of Symbyax.

What is Actos?

Actos has active ingredients of pioglitazone hydrochloride. It is often used in diabetes. eHealthMe is studying from 49,754 Actos users. Check the latest studies of Actos.

On Jul, 11, 2026

30 people who take Symbyax and Actos together, and have interactions are studied.

What are the common drug interactions of Symbyax and Actos, by gender? *:

female:

Carpal tunnel decompression
Cataract (clouding of the lens inside the eye)
Cellulitis (infection under the skin)
Cellulitis orbital (acute spread of infection into the eye socket)
Conjunctivitis (pink eye)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Diabetic complication
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Gestational diabetes (diabetes in pregnancy)

male:

Weight increased
Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)
Diabetes mellitus inadequate control
Loss of consciousness
Psychotic disorder
Respiratory arrest (cessation of normal respiration due to failure of the lungs to function effectively)
Aggression
Asthenia (weakness)
Constipation
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)

What are the common drug interactions of Symbyax and Actos, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Obesity (having too much body fat)

30-39:

Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Diabetic nephropathy (diabetic kidney disease)
Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)
Obesity (having too much body fat)
Renal failure (kidney dysfunction)
Renal failure chronic (long lasting kidney dysfunction)
Diabetes mellitus inadequate control
Neuropathy peripheral (surface nerve damage)
Nephropathy (damage to or disease of a kidney)
Organic erectile dysfunction (inability to achieve or maintain an erection long enough to engage in sexual intercourse)

40-49:

Cellulitis orbital (acute spread of infection into the eye socket)
Conjunctivitis (pink eye)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Diabetes mellitus inadequate control
Diabetic complication
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Gestational diabetes (diabetes in pregnancy)
Glycosuria (excretion of glucose into the urine)
Hospitalisation

50-59:

Angina pectoris (chest pain due to ischemia of the heart muscle)
Arteriosclerosis coronary artery (thickening and hardening of arteries- coronary artery)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Bladder discomfort
Cardiac disorder
Cardiomyopathy (weakening of the heart muscle)
Chest pain
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Coeliac disease (simple food intolerance)
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)

60+:

Blood creatine phosphokinase increased
Weight increased
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Depressed level of consciousness
Haematocrit decreased
Haematuria (presence of blood in urine)
Haemoglobin decreased
Hallucination (an experience involving the perception of something not present)
Incontinence (lack of moderation or self-control)
Lymphocyte count decreased

What are the existing conditions these people have? *

Bipolar Disorder (mood disorder): 8 people, 26.67%
Affective Disorder (mental disorder): 6 people, 20.00%
Agitation (state of anxiety or nervous excitement): 6 people, 20.00%
Schizoaffective Disorder (a mental disorder characterized by disordered thought): 6 people, 20.00%
Stress And Anxiety: 4 people, 13.33%
Attention Deficit Hyperactivity Disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness): 3 people, 10.00%
Type 2 Diabetes: 3 people, 10.00%
Peptic Ulcer Haemorrhage (peptic ulcer bleeding): 2 people, 6.67%
Parkinson's Disease: 2 people, 6.67%
Neuropathy Peripheral (surface nerve damage): 2 people, 6.67%

* Approximation only. Some reports may have incomplete information.

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